Protein MCM10 Homolog

Preferred Label : Protein MCM10 Homolog;

NCIt synonyms : MCM10 Homolog; Minichromosome Maintenance Protein 10; HsMCM10; MCM10 Minichromosome Maintenance Deficient 10; Minichromosome Maintenance Protein-10;

NCIt definition : Protein MCM10 homolog (875 aa, 98 kDa) is encoded by the human MCM10 gene. This protein is involved in both replication and maintenance of DNA.;

NCIt note : MCM10 is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. MCM10 interacts with ORC2 and with MCM2 and MCM6 of the hexameric MCM2-7 protein complex, a key component of the pre-replication complex and likely involved in formation of replication forks and in recruitment of replication factors. Involved in S phase progression, MCM10 may release MCM2-7 from the origin of replication triggering DNA replication.;

Details

Origin ID

C33908;

UMLS CUI

C1453309;

OMIM relation
- Minichromosome maintenance complex component 10 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MCM10 protein, human [MeSH concept]
- MCM10 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- MCM10 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- MCM Protein [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Replication [NCIt concept]
- Replication Initiation [NCIt concept]
- S Phase Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients