Replication Initiation

Preferred Label : Replication Initiation;

NCIt synonyms : DNA Replication Initiation;

NCIt definition : DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. (from MedLine 11395402);

Details

Origin ID

C28677;

UMLS CUI

C1155650;

Automatic exact mappings (from CISMeF team)
- DNA replication initiation [GO term]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- DNA replication initiation [GO term]
biological_process_involves_gene_product
- Cell Division Control Protein 45 Homolog [NCIt concept]
- Cell Division Control Protein 6 Homolog [NCIt concept]
- Cell Division Cycle 7-Related Protein Kinase [NCIt concept]
- DNA Primase Large Subunit [NCIt concept]
- DNA Primase Small Subunit [NCIt concept]
- DNA Replication Factor Cdt1 [NCIt concept]
- DNA Replication Initiation Protein [NCIt concept]
- DNA Replication Licensing Factor MCM2 [NCIt concept]
- DNA Replication Licensing Factor MCM3 [NCIt concept]
- DNA Replication Licensing Factor MCM4 [NCIt concept]
- DNA Replication Licensing Factor MCM5 [NCIt concept]
- DNA Replication Licensing Factor MCM6 [NCIt concept]
- DNA Replication Licensing Factor MCM7 [NCIt concept]
- Leucine-Rich Repeat and WD Repeat-Containing Protein 1 [NCIt concept]
- Licensing Factor [NCIt concept]
- Origin Recognition Complex Subunit 1 [NCIt concept]
- Origin Recognition Complex Subunit 2 [NCIt concept]
- Origin Recognition Complex Subunit 3 [NCIt concept]
- Origin Recognition Complex Subunit 4 [NCIt concept]
- Origin Recognition Complex Subunit 5 [NCIt concept]
- Origin Recognition Complex Subunit 6 [NCIt concept]
- Protein MCM10 Homolog [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta [NCIt concept]
- Transcriptional Activator Protein Pur-Alpha [NCIt concept]
process_involves_gene
- CDC45 Gene [NCIt concept]
- CDC45 wt Allele [NCIt concept]
- CDC6 Gene [NCIt concept]
- CDC6 wt Allele [NCIt concept]
- CDC7 Gene [NCIt concept]
- CDC7 wt Allele [NCIt concept]
- CDT1 Gene [NCIt concept]
- CDT1 wt Allele [NCIt concept]
- LRWD1 Gene [NCIt concept]
- LRWD1 wt Allele [NCIt concept]
- Licensing Factor Gene [NCIt concept]
- MCM2 Gene [NCIt concept]
- MCM2 wt Allele [NCIt concept]
- MCM3 Gene [NCIt concept]
- MCM3 wt Allele [NCIt concept]
- MCM4 Gene [NCIt concept]
- MCM4 wt Allele [NCIt concept]
- MCM5 Gene [NCIt concept]
- MCM5 wt Allele [NCIt concept]
- MCM6 Gene [NCIt concept]
- MCM6 wt Allele [NCIt concept]
- MCM7 Gene [NCIt concept]
- MCM7 wt Allele [NCIt concept]
- ORC1 Gene [NCIt concept]
- ORC1 wt Allele [NCIt concept]
- ORC2 Gene [NCIt concept]
- ORC2 wt Allele [NCIt concept]
- ORC3 Gene [NCIt concept]
- ORC3 wt Allele [NCIt concept]
- ORC4 Gene [NCIt concept]
- ORC4 wt Allele [NCIt concept]
- ORC5 Gene [NCIt concept]
- ORC5 wt Allele [NCIt concept]
- ORC6 Gene [NCIt concept]
- ORC6 wt Allele [NCIt concept]
- PPP2R3B Gene [NCIt concept]
- PPP2R3B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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