Preferred Label : Cell Division Control Protein 45 Homolog;
NCIt synonyms : CDC45; PORC-PI-1; CDC45 (Cell Division Cycle 45, S. cerevisiae, Homolog)-Like; Cell Division Cycle 45, S. cerevisiae, Homolog-Like; Cell Division Cycle 45-Like 2; CDC45-Like; CDC45L; CDC45 Cell Division Cycle 45-Like (S. cerevisiae); CDC45L2; CDC45-Related Protein; CDC45 Cell Division Cycle 45-Like; Cell Division Cycle 45 Homolog; CDC45 Cell Division Cycle 45 Homolog;
NCIt definition : Cell division control protein 45 homolog (566 aa, 66 kDa) is encoded by the human
CDC45 gene. This protein is involved in the initiation of genomic DNA replication.;
NCIt note : CDC45-Related Protein, encoded by the CDC45L gene, was identified by its strong similarity
with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation
of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex
including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase,
which is important for early steps of DNA replication in eukaryotes. CDC45-Related
Protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of
the similar gene in Xenopus suggest that this protein play a pivotal role in the loading
of DNA polymerase alpha onto chromatin. (LocusLink);
Origin ID : C28673;
UMLS CUI : C0755538;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
