Cell Cycle Pathway

Preferred Label : Cell Cycle Pathway;

NCIt related terms : Cell Cycle;

Alternative definition : KEGG: Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.;

NCI Metathesaurus CUI : CL322969;

KEGG ID : hsa04110;

Details

Origin ID

C38794;

UMLS CUI

C0007586;

Automatic exact mappings (from CISMeF team)
- Cell cycle [EDAM topic]
- cell cycle [OBI concept]
- cell cycle [MeSH concept]
- cell cycle [GO term]
- cell cycle [MeSH Descriptor]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- Cell cycle [OMIConto structure]
- cell cycle [GO term]
- cell cycle [MeSH concept]
- cell cycle [MeSH Descriptor]
has_gene_product_element
- 14-3-3 Protein Epsilon [NCIt concept]
- 14-3-3 Protein Sigma [NCIt concept]
- 14-3-3 Protein Theta [NCIt concept]
- ATP-Dependent DNA Helicase DDX11 [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Cell Division Control Protein 45 Homolog [NCIt concept]
- Cell Division Control Protein 6 Homolog [NCIt concept]
- Cell Division Cycle 7-Related Protein Kinase [NCIt concept]
- Cohesin Subunit SA-1 [NCIt concept]
- Cohesin Subunit SA-2 [NCIt concept]
- Cyclin-A2 [NCIt concept]
- Cyclin-Dependent Kinase 1 [NCIt concept]
- Cyclin-Dependent Kinase 2 [NCIt concept]
- Cyclin-Dependent Kinase 4 [NCIt concept]
- Cyclin-Dependent Kinase 4 Inhibitor D [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
- Cyclin-Dependent Kinase 7 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1 [NCIt concept]
- DNA Replication Licensing Factor MCM2 [NCIt concept]
- DNA Replication Licensing Factor MCM3 [NCIt concept]
- DNA Replication Licensing Factor MCM4 [NCIt concept]
- DNA Replication Licensing Factor MCM5 [NCIt concept]
- DNA Replication Licensing Factor MCM6 [NCIt concept]
- DNA Replication Licensing Factor MCM7 [NCIt concept]
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- Double-Strand-Break Repair Protein Rad21 Homolog [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- Fizzy-Related Protein Homolog [NCIt concept]
- G1/S-Specific Cyclin-D3 [NCIt concept]
- G1/S-Specific Cyclin-E1 [NCIt concept]
- G2/Mitotic-Specific Cyclin-B1 [NCIt concept]
- G2/Mitotic-Specific Cyclin-B3 [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Beta [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- Histone Deacetylase 2 [NCIt concept]
- M-Phase Inducer Phosphatase 1 [NCIt concept]
- Membrane-Associated Tyrosine- and Threonine-Specific Cdc2-Inhibitory Kinase [NCIt concept]
- Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 [NCIt concept]
- Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 Beta [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2A [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2B [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Origin Recognition Complex Subunit 1 [NCIt concept]
- Origin Recognition Complex Subunit 2 [NCIt concept]
- Origin Recognition Complex Subunit 3 [NCIt concept]
- Origin Recognition Complex Subunit 4 [NCIt concept]
- Origin Recognition Complex Subunit 5 [NCIt concept]
- Origin Recognition Complex Subunit 6 [NCIt concept]
- Proliferating Cell Nuclear Antigen [NCIt concept]
- Protein DBF4 homolog A [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Retinoblastoma-Like Protein 1 [NCIt concept]
- S-Phase Kinase-Associated Protein 1 [NCIt concept]
- S-Phase Kinase-Associated Protein 2 [NCIt concept]
- Securin [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Serine/Threonine-Protein Kinase ATR [NCIt concept]
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]
- Serine/Threonine-Protein Kinase Chk2 [NCIt concept]
- Serine/Threonine-Protein Kinase PLK1 [NCIt concept]
- Structural Maintenance of Chromosomes Protein 3 [NCIt concept]
- Transcription Factor Dp-1 [NCIt concept]
- Transcription Factor Dp-2 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Transcription Factor E2F2 [NCIt concept]
- Transcription Factor E2F3 [NCIt concept]
- Transcription Factor E2F4 [NCIt concept]
- Transcription Factor E2F5 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
- Wee1-Like Protein Kinase [NCIt concept]
- Zinc Finger and BTB Domain-Containing Protein 17 [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- ATM wt Allele [NCIt concept]
- ATR wt Allele [NCIt concept]
- BUB1 wt Allele [NCIt concept]
- BUB1B wt Allele [NCIt concept]
- CCNA2 wt Allele [NCIt concept]
- CCNB1 wt Allele [NCIt concept]
- CCNB3 wt Allele [NCIt concept]
- CCND2 wt Allele [NCIt concept]
- CCND3 wt Allele [NCIt concept]
- CCNE1 wt Allele [NCIt concept]
- CDC25A wt Allele [NCIt concept]
- CDC45 wt Allele [NCIt concept]
- CDC6 wt Allele [NCIt concept]
- CDC7 wt Allele [NCIt concept]
- CDK1 wt Allele [NCIt concept]
- CDK2 wt Allele [NCIt concept]
- CDK4 wt Allele [NCIt concept]
- CDK6 wt Allele [NCIt concept]
- CDK7 wt Allele [NCIt concept]
- CDKN1A wt Allele [NCIt concept]
- CDKN2D wt Allele [NCIt concept]
- CHEK1 wt Allele [NCIt concept]
- CHEK2 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- CUL1 wt Allele [NCIt concept]
- DBF4 wt Allele [NCIt concept]
- DDX11 wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- E2F2 wt Allele [NCIt concept]
- E2F3 wt Allele [NCIt concept]
- E2F4 wt Allele [NCIt concept]
- E2F5 wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- FZR1 wt Allele [NCIt concept]
- GADD45A wt Allele [NCIt concept]
- GADD45B wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HDAC1 wt Allele [NCIt concept]
- HDAC2 wt Allele [NCIt concept]
- MAD2L1 wt Allele [NCIt concept]
- MAD2L2 wt Allele [NCIt concept]
- MCM2 wt Allele [NCIt concept]
- MCM3 wt Allele [NCIt concept]
- MCM4 wt Allele [NCIt concept]
- MCM5 wt Allele [NCIt concept]
- MCM6 wt Allele [NCIt concept]
- MCM7 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- ORC1 wt Allele [NCIt concept]
- ORC2 wt Allele [NCIt concept]
- ORC3 wt Allele [NCIt concept]
- ORC4 wt Allele [NCIt concept]
- ORC5 wt Allele [NCIt concept]
- ORC6 wt Allele [NCIt concept]
- PCNA wt Allele [NCIt concept]
- PKMYT1 wt Allele [NCIt concept]
- PLK1 wt Allele [NCIt concept]
- PRKDC wt Allele [NCIt concept]
- PTTG1 wt Allele [NCIt concept]
- RAD21 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RBL1 wt Allele [NCIt concept]
- SFN wt Allele [NCIt concept]
- SKP1 wt Allele [NCIt concept]
- SKP2 wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- SMC3 wt Allele [NCIt concept]
- STAG1 wt Allele [NCIt concept]
- STAG2 wt Allele [NCIt concept]
- TFDP1 wt Allele [NCIt concept]
- TFDP2 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- WEE1 wt Allele [NCIt concept]
- YWHAE wt Allele [NCIt concept]
- YWHAQ wt Allele [NCIt concept]
- ZBTB17 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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