Tyrosine-Protein Kinase ABL1

Preferred Label : Tyrosine-Protein Kinase ABL1;

NCIt synonyms : P150; ABL Tyrosine Kinase; c-ABL Protein; ABL1; Abelson Tyrosine-Protein Kinase 1; Proto-Oncogene Tyrosine-Protein Kinase ABL; Proto-Oncogene c-Abl; EC 2.7.10.2; ABL1 Tyrosine Kinase; Abelson Murine Leukemia Viral Oncogene Homolog 1;

NCIt definition : Tyrosine-protein kinase ABL1 (1130 aa, 123 kDa) is encoded by the human ABL1 gene. This protein is involved in tyrosine phosphorylation, signal transduction, cell motility, cell adhesion, receptor endocytosis, autophagy and apoptosis.;

Details

Origin ID

C17390;

UMLS CUI

C1439337;

OMIM relation
- Abl protooncogene 1, nonreceptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ABL1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_gene_product_variant
- ABL1 NP_005148.2:p.A34V [NCIt concept]
- ABL1 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- LIS1 Pathway [NCIt concept]
- Lissencephaly-1 Gene in Neuronal Migration and Development [NCIt concept]
- Neurotrophic Factor-Mediated NTRK1 Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
- Ribosomal Biogenesis Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
- p53 Pathway for Transcriptional Regulation [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcription [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- FLT3/ABL/Aurora Kinase Inhibitor KW-2449 [NCIt concept]
- Saracatinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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