Preferred Label : FLT3/ABL/Aurora Kinase Inhibitor KW-2449;
NCIt related terms : KW-2449;
NCIt definition : An orally available inhibitor of FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2),
the tyrosine kinase ABL, and aurora kinases, with potential antineoplastic activity.
Upon administration, FLT3/ABL/Aurora kinase inhibitor KW-2449 specifically binds to
and inhibits both wild-type and mutated forms of FLT3, ABL and aurora kinases, which
both interferes with the activation of signal transduction pathways mediated by these
kinases and reduces the proliferation of susceptible cancer cells. FLT3 and ABL kinases
are upregulated in certain tumor cells and play important roles in tumor cell proliferation
and metastasis. Aurora kinases, serine-threonine kinases overexpressed by a wide variety
of cancer cell types, play essential roles in mitotic checkpoint control.;
UNII : 2D9N67F58G;
CAS number : 841258-76-2;
Molecule name : KW-2449;
Origin ID : C116858;
UMLS CUI : C1831922;
Currated CISMeF NLP mapping
- KW 2449 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- KW 2449 [MeSH Supplementary Concept]
- chemical_or_drug_affects_gene_product
- concept_is_in_subset
- has_target
