Receptor-Type Tyrosine-Protein Kinase FLT3

Preferred Label : Receptor-Type Tyrosine-Protein Kinase FLT3;

NCIt synonyms : FLT3; FLT-3; Flt-3 Receptor; Stem Cell Tyrosine Kinase 1; CD135 Antigen; Fms-Related Tyrosine Kinase-3; FLK-2; FL Cytokine Receptor; Fms-Related Tyrosine Kinase 3; Fetal Liver Kinase-2; STK-1;

NCIt definition : Receptor-type tyrosine-protein kinase FLT3 (993 aa, 113 kDa) is encoded by the human FLT3 gene. This protein plays a role in tyrosine phosphorylation and the proliferation and survival of hematopoietic stem cells and dendritic cells.;

Details

Origin ID

C26202;

UMLS CUI

C0251006;

OMIM relation
- Fms-related tyrosine kinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FLT3 protein, human [MeSH concept]
- FLT3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FLT3 Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Recombinant Flt3 Ligand [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- FLT3 NP_004110.2:p.A690V [NCIt concept]
- FLT3 NP_004110.2:p.D835X [NCIt concept]
- FLT3 NP_004110.2:p.D839E [NCIt concept]
- FLT3 NP_004110.2:p.D839G [NCIt concept]
- FLT3 NP_004110.2:p.F590_R595delinsL [NCIt concept]
- FLT3 NP_004110.2:p.F594C [NCIt concept]
- FLT3 NP_004110.2:p.F594Y [NCIt concept]
- FLT3 NP_004110.2:p.F691L [NCIt concept]
- FLT3 NP_004110.2:p.I836X [NCIt concept]
- FLT3 NP_004110.2:p.L576R [NCIt concept]
- FLT3 NP_004110.2:p.M664I [NCIt concept]
- FLT3 NP_004110.2:p.N676K [NCIt concept]
- FLT3 NP_004110.2:p.N676S [NCIt concept]
- FLT3 NP_004110.2:p.N841X [NCIt concept]
- FLT3 NP_004110.2:p.V592A [NCIt concept]
- FLT3 NP_004110.2:p.V592G [NCIt concept]
- FLT3 NP_004110.2:p.Y589D [NCIt concept]
- FLT3 NP_004110.2:p.Y599C [NCIt concept]
- FLT3 NP_004110.2:p.Y842C [NCIt concept]
- FLT3 NP_004110.2:p.Y842X [NCIt concept]
- FLT3 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Erythrocyte Differentiation Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Myeloid Leukemia [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- AXL/FLT3 Inhibitor TT-00973 [NCIt concept]
- AXL/FLT3/NTRK Inhibitor HH30134 [NCIt concept]
- AXL/FLT3/VEGFR2 Inhibitor KC1036 [NCIt concept]
- Ad-hCMV-Flt3L [NCIt concept]
- Allogeneic Calibrated Release IL-15-expressing Logic-Gated Gene Circuit Anti-CD33/FLT3 CAR-NK Cells SENTI-202 [NCIt concept]
- Anti-FLT3 Antibody-drug Conjugate AGS62P1 [NCIt concept]
- Anti-FLT3 Monoclonal Antibody 4G8-SDIEM [NCIt concept]
- Anti-FLT3 Monoclonal Antibody IMC-EB10 [NCIt concept]
- Anti-FLT3/CD3 Bispecific Antibody CLN-049 [NCIt concept]
- Autologous Anti-FLT3 CAR T Cells TAA05 [NCIt concept]
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Carbon C 14 Gilteritinib [NCIt concept]
- Cediranib Maleate [NCIt concept]
- Clifutinib [NCIt concept]
- Clifutinib Besylate [NCIt concept]
- Denfivontinib [NCIt concept]
- Denfivontinib Hydrochloride [NCIt concept]
- Dovitinib Lactate [NCIt concept]
- Dovitinib Lactate Anhydrous [NCIt concept]
- Emirodatamab [NCIt concept]
- FLT3 Agonist-Fc Fusion Protein GS-3583 [NCIt concept]
- FLT3 Inhibitor BMF-500 [NCIt concept]
- FLT3 Inhibitor FF-10101 Succinate [NCIt concept]
- FLT3 Inhibitor XY0206 [NCIt concept]
- FLT3 Tyrosine Kinase Inhibitor TTT-3002 [NCIt concept]
- FLT3/ABL/Aurora Kinase Inhibitor KW-2449 [NCIt concept]
- FLT3/CDK4/6 Inhibitor FLX925 [NCIt concept]
- FLT3/KIT/CSF1R Inhibitor NMS-03592088 [NCIt concept]
- Fedratinib [NCIt concept]
- Fedratinib Hydrochloride [NCIt concept]
- Flonoltinib Maleate [NCIt concept]
- Flt3/MerTK Inhibitor MRX-2843 [NCIt concept]
- Gilteritinib [NCIt concept]
- Gilteritinib Fumarate [NCIt concept]
- Luxeptinib [NCIt concept]
- Midostaurin [NCIt concept]
- Mobinitinib [NCIt concept]
- Modified Vaccinia Virus Ankara Expressing Flt3L/OX40L MQ710 [NCIt concept]
- Pacritinib [NCIt concept]
- Pacritinib Citrate [NCIt concept]
- Pacritinib Hydrochloride [NCIt concept]
- Pexidartinib [NCIt concept]
- Pexidartinib Hydrochloride [NCIt concept]
- Ponatinib Hydrochloride [NCIt concept]
- Quizartinib [NCIt concept]
- Quizartinib Dihydrochloride [NCIt concept]
- Receptor Tyrosine Kinase Inhibitor R1530 [NCIt concept]
- Sorafenib Tosylate [NCIt concept]
- Sunitinib [NCIt concept]
- Sunitinib Malate [NCIt concept]
- Tandutinib [NCIt concept]
- Tuspetinib [NCIt concept]
- VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813 [NCIt concept]
- Zotiraciclib Citrate [NCIt concept]
- c-Met/FLT3/TRK/CDK8/19 Inhibitor TSN084 [NCIt concept]

Keyword's position in hierarchy(ies) :

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