Preferred Label : Ad-hCMV-Flt3L;
NCIt definition : A human serotype 5, replication-defective, first generation adenoviral vector, with
the viral E1a and E3 protein encoding regions deleted, which is engineered to express
the soluble, immune-mediated stimulatory gene human fms-like tyrosine kinase 3 ligand
(Flt3L), under the transcriptional control of the CMV promoter, with potential immunostimulating
activity. Upon administration, Ad-hCMV-Flt3L is transduced into tumor cells and Flt3L
is expressed. Flt3L stimulates both the proliferation of dendritic cells (DCs) and
their migration to the tumor site. Upon exposure to the tumor-associated antigens
(TAA) released from dying glioma cells, which were killed by thymidine kinase-mediated
valacyclovir-induced tumor cell death, the DCs initiate a specific immune response
against any remaining TAA-expressing tumor cells. Flt3L is a hematopoietic growth
factor and ligand for the Flt3 tyrosine kinase receptor.;
NCI Metathesaurus CUI : CL447164;
Origin ID : C105813;
UMLS CUI : C3831603;
Semantic type(s)
- concept_is_in_subset
- has_target
