" /> Quizartinib - CISMeF





Preferred Label : Quizartinib;

NCIt synonyms : FLT-3 Kinase Inhibitor AC220; (2E)-N-(4-(3-Chloro-4-Fluoroanilino)-7-(((3S)-Oxolan-3-Yl)Oxy)Quinoxazolin-6-yl)-4-(Dimethylamino)but-2-Enamide; N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo [2,1-b] [1,3] benzothiazol 2-yl]phenyl}urea;

NCIt definition : An orally available small molecule with potential antineoplastic activity. Quizartinib selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.;

UNII : 7LA4O6Q0D3;

InChIKey : CVWXJKQAOSCOAB-UHFFFAOYSA-N;

CAS number : 950769-58-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 950769-58-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Vanflyta;

Molecule name : AC-220; AC010220; ASP-2689; ASP 2689;

Chemical formula : C29H32N6O4S;

Codes from synonyms : 426;

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14/05/2024


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