Preferred Label : Quizartinib Dihydrochloride;
NCIt synonyms : Urea, N-(5-(1,1-dimethylethyl)-3-isoxazolyl)-N'-(4-(7-(2-(4-morpholinyl) ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)-,
Hydrochloride (1:2); N-(5-Tert-butyl-isoxazol-3-yl)-N'-(4-(7-(2-morpholin-4-ylethoxy)imidazo(2,1-b)(1,3)benzothiazol-2-yl)phenyl)urea
Dihydrochloride;
NCIt definition : The dihydrochloride salt form of quizartinib, an orally available small molecule with
potential antineoplastic activity. Quizartinib selectively inhibits class III receptor
tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating
factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet
derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent
leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive
activation, are the most frequent genetic alterations in acute myeloid leukemia (AML)
and occur in approximately one-third of AML cases.;
UNII : WK7Q6ZIZ10;
InChIKey : DHYPGRVMIOATAE-UHFFFAOYSA-N;
CAS number : 1132827-21-4;
Molecule name : AC220 2HCL; AC010220 2HCl;
Chemical formula : C29H32N6O4S.2ClH;
Origin ID : C97272;
UMLS CUI : C3273320;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
