Mast/Stem Cell Growth Factor Receptor Kit

Preferred Label : Mast/Stem Cell Growth Factor Receptor Kit;

NCIt synonyms : C-KIT; SCF Receptor; Mast Cell Growth Factor Receptor; KIT; SCFR; EC 2.7.10.1; Proto-Oncogene c-Kit; CD117 Antigen; Piebald Trait Protein; Tyrosine-Protein Kinase Kit; p145 c-kit; PBT; v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Antigen CD117; Proto-Oncogene Tyrosine-Protein Kinase Kit;

NCIt related terms : CD117; c-kit receptor; KIT (CD117); stem cell factor receptor;

NCIt definition : Mast/stem cell growth factor receptor Kit (976 aa, 110 kDa) is encoded by the human KIT gene. This protein is involved in cell survival, tyrosine phosphorylation and ligand-mediated signaling.;

Alternative definition : NCI-GLOSS: A protein on the surface of some cells that binds to biologic substance called stem cell factor (SCF). SCF causes certain types of blood cells to grow. The stem cell factor receptor is found at high levels or in a changed form on some types of cancer cells. This may cause these cells to grow rapidly when SCF is present. The stem cell factor receptor is a type of receptor tyrosine kinase.;

NCI Metathesaurus CUI : CL964236;

Codes from synonyms : CDR0000044329; CDR0000633224;

Details

Origin ID

C17328;

UMLS CUI

C3853650;

OMIM relation
- Kit protooncogene, receptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Sarcoma Baseline Form [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- KIT Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Ancestim [NCIt concept]
- Recombinant Human Stem Cell Factor [NCIt concept]
- Semaxanib [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- KIT NP_000213.1:p.A829P [NCIt concept]
- KIT NP_000213.1:p.D816V [NCIt concept]
- KIT NP_000213.1:p.D820Y [NCIt concept]
- KIT NP_000213.1:p.G648D [NCIt concept]
- KIT NP_000213.1:p.I653T [NCIt concept]
- KIT NP_000213.1:p.K642E [NCIt concept]
- KIT NP_000213.1:p.K818Q [NCIt concept]
- KIT NP_000213.1:p.L576P [NCIt concept]
- KIT NP_000213.1:p.L647F [NCIt concept]
- KIT NP_000213.1:p.L813P [NCIt concept]
- KIT NP_000213.1:p.L831P [NCIt concept]
- KIT NP_000213.1:p.L859P [NCIt concept]
- KIT NP_000213.1:p.L862P [NCIt concept]
- KIT NP_000213.1:p.N822K [NCIt concept]
- KIT NP_000213.1:p.N822Y [NCIt concept]
- KIT NP_000213.1:p.S590I [NCIt concept]
- KIT NP_000213.1:p.S840I [NCIt concept]
- KIT NP_000213.1:p.S850G [NCIt concept]
- KIT NP_000213.1:p.V559A [NCIt concept]
- KIT NP_000213.1:p.V559D [NCIt concept]
- KIT NP_000213.1:p.V654A [NCIt concept]
- KIT NP_000213.1:p.V852I [NCIt concept]
- KIT NP_000213.1:p.W557R [NCIt concept]
- KIT NP_000213.1:p.Y846C [NCIt concept]
- KIT Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Gastrointestinal Stromal Tumor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Amuvatinib [NCIt concept]
- Anti-CD117/Amanitin Antibody-drug Conjugate MGTA-117 [NCIt concept]
- Anti-c-KIT Monoclonal Antibody CDX 0158 [NCIt concept]
- Avapritinib [NCIt concept]
- Bezuclastinib [NCIt concept]
- Briquilimab [NCIt concept]
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Dasatinib [NCIt concept]
- Dasatinib Anhydrous [NCIt concept]
- Dovitinib [NCIt concept]
- Elenestinib [NCIt concept]
- Fluorine F 18 Dasatinib [NCIt concept]
- Ibcasertib [NCIt concept]
- Imatinib [NCIt concept]
- Imatinib Mesylate [NCIt concept]
- Masitinib Mesylate [NCIt concept]
- Midostaurin [NCIt concept]
- Motesanib Diphosphate [NCIt concept]
- Olverembatinib [NCIt concept]
- PDGFR alpha/KIT Mutant-specific Inhibitor NB003 [NCIt concept]
- Pan-variant KIT Inhibitor THE-630 [NCIt concept]
- Pazopanib [NCIt concept]
- Pazopanib Hydrochloride [NCIt concept]
- Pexidartinib [NCIt concept]
- Pexidartinib Hydrochloride [NCIt concept]
- Quizartinib [NCIt concept]
- Regorafenib [NCIt concept]
- Regorafenib Hydrate [NCIt concept]
- Ripretinib [NCIt concept]
- Rivoceranib [NCIt concept]
- Semaxanib [NCIt concept]
- Sorafenib Tosylate [NCIt concept]
- Sunitinib [NCIt concept]
- Sunitinib Malate [NCIt concept]
- Tandutinib [NCIt concept]
- Telatinib Mesylate [NCIt concept]
- VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813 [NCIt concept]

Keyword's position in hierarchy(ies) :

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