Preferred Label : Fluorine F 18 Dasatinib;
NCIt synonyms : [18F] SKI-249380; F-SKI249380; [18F]-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-fluoroethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide; SKI-249380 F-18; Fluorine F 18 SKI-249380; Fluoro(F18)-Dasatinib;
NCIt related terms : FLUORO-DASATINIB F-18;
NCIt definition : A radioconjugate composed of a derivative of the multi-targeted kinase inhibitor dasatinib
conjugated to the radioisotope fluorine F 18, with potential imaging activity during
positron emission tomography (PET). Upon administration of fluorine F 18 dasatinib,
dasatinib targets and binds to Bcr/Abl, SRC-family protein-tyrosine kinases, c-Kit
and platelet-derived growth factor receptor (PDGFR). Upon binding, the fluorine F
18 moiety allows PET imaging of tumor cells and can be used as a tracer for the biodistribution
of dasatinib.;
UNII : KD0C0X4Y6E;
InChIKey : PLZOWXHKTJJSQR-MIGPCILRSA-N;
CAS number : 957218-03-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 957218-03-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
NCI Metathesaurus CUI : CL453984;
Origin ID : C111576;
UMLS CUI : C4722542;
Semantic type(s)
- concept_is_in_subset
- has_target
