NCIt definition : A fusion protein encoded by the BCR/ABL1 fusion gene. This protein is comprised of
the N-terminus of the breakpoint cluster region protein fused to almost the entire
tyrosine-protein kinase ABL1 protein.;
NCIt note : The BCR/ABL1 fusion protein is a constitutively activated tyrosine kinase and has
a cytoplasmic localization, in contrast with the mostly nuclear localization of the
tyrosine-protein kinase ABL1 protein. (Atlas of Genetics and Cytogenetics in Oncology
and Haematology);