" /> Bafetinib - CISMeF





Preferred Label : Bafetinib;

NCIt synonyms : Dual Bcr-Abl/Lyn Tyrosine Kinase Inhibitor INNO-406; Benzamide, N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3- (dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)-;

NCIt definition : An orally active 2-phenylaminopyrimidine derivative with potential antineoplastic activity. INNO-406 specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). Furthermore, this agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types. The inhibitory effect of INNO-406 on these specific tyrosine kinases decreases cellular proliferation and induces apoptosis. A high percentage of CML patients are refractory to imatinib, which sometimes results from point mutations occurring in the kinase domain of the Bcr/Abl fusion product. Due to its dual inhibitory activity, INNO-406 has been shown to overcome this particular drug resistance and to be a potent and effective agent in the treatment of imatinib-resistant CML.;

UNII : NVW4Z03I9B;

InChIKey : ZGBAJMQHJDFTQJ-DEOSSOPVSA-N;

CAS number : 859212-16-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 859212-16-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : INNO-406; NS-187; CNS-9;

Chemical formula : C30H31F3N8O;

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14/05/2024


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