Dasatinib Anhydrous

Preferred Label : Dasatinib Anhydrous;

NCIt definition : An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.;

UNII : X78UG0A0RN;

InChIKey : ZBNZXTGUTAYRHI-UHFFFAOYSA-N;

CAS number : 302962-49-8;

Chemical formula : C22H26ClN7O2S;

ChEBI ID : CHEBI:49375;

Details

Origin ID

C74556;

UMLS CUI

C2699562;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dasatinib anhydrous (substance) [SNOMED CT concept]
- N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- SRC Family Tyrosine Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- BCR/ABL1 Fusion Protein [NCIt concept]
- Ephrin Type-A Receptor 2 [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor Beta [NCIt concept]
- Tyrosine-Protein Kinase CSK [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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