NCIt definition : An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine
kinases. Dasatinib binds to and inhibits the growth-promoting activities of these
kinases. Apparently because of its less stringent binding affinity for the BCR-ABL
kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic
myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family
protein-tyrosine kinases interact with variety of cell-surface receptors and participate
in intracellular signal transduction pathways; tumorigenic forms can occur through
altered regulation or expression of the endogenous protein and by way of virally-encoded
kinase genes.;
UNII : X78UG0A0RN;
InChIKey : ZBNZXTGUTAYRHI-UHFFFAOYSA-N;
CAS number : 302962-49-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 302962-49-8
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