Platelet-Derived Growth Factor Receptor Beta

Preferred Label : Platelet-Derived Growth Factor Receptor Beta;

NCIt synonyms : Beta Platelet-Derived Growth Factor Receptor; PDGFRB; CD140b Antigen; PDGF-R-Beta; EC 2.7.1.112; Platelet-Derived Growth Factor Receptor Beta Polypeptide; PDGFR-Beta; CD140b; PDGFR-1; CD140 Antigen-Like Family Member B; Platelet-Derived Growth Factor Receptor 1; Beta-Type Platelet-Derived Growth Factor Receptor; EC 2.7.10.1;

NCIt definition : Platelet-derived growth factor receptor beta (1106 aa, 124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine phosphorylation and ligand-dependent signal transduction.;

NCIt note : The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia. (from LocusLink);

Details

Origin ID

C30164;

UMLS CUI

C3853695;

Currated CISMeF NLP mapping
- receptor, Platelet-Derived growth factor beta [MeSH concept]
- receptor, platelet-derived growth factor beta [MeSH Descriptor]
OMIM relation
- Platelet-derived growth factor receptor, beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- PDGFRB Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- PDGFRB NP_002600.1:p.T681I [NCIt concept]
- PDGFRB Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Angiogenesis Inhibitor JI-101 [NCIt concept]
- Dasatinib [NCIt concept]
- Dasatinib Anhydrous [NCIt concept]
- Orantinib [NCIt concept]
- Receptor Tyrosine Kinase Inhibitor R1530 [NCIt concept]
- Sorafenib [NCIt concept]
- Sorafenib Tosylate [NCIt concept]
- Tandutinib [NCIt concept]
- Telatinib Mesylate [NCIt concept]

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