Chronic Myeloid Leukemia, BCR-ABL1 Positive

Preferred Label : Chronic Myeloid Leukemia, BCR-ABL1 Positive;

NCIt synonyms : BCR-ABL Positive Chronic Myelogenous Leukemia; Chronic Myelocytic Leukemia; Chronic Granulocytic Leukemia; Chronic Myelogenous Leukemias; CML; Chronic Myeloid Leukemia; Hematopoeitic - Chronic Myelocytic Leukemia (CML); CML - Chronic Myelogenous Leukemia; Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myeloid Leukemia, BCR::ABL1 Positive;

NCIt related terms : Chronic myelogenous leukemia, BCR-ABL positive; chronic myelogenous leukemia; Chronic Myelogenous Leukemia (CML);

NCIt definition : A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.;

Alternative definition : NCI-GLOSS: A slowly progressing disease in which too many white blood cells are made in the bone marrow.;

Neoplastic status : Malignant;

ICD-O code : 9863/3; 9875/3;

Codes from synonyms : CDR0000046754; CDR0000046755; CDR0000044382; CDR0000044901;

Details

Origin ID

C3174;

UMLS CUI

C1292771;

Currated CISMeF NLP mapping
- CML [MedDRA LLT]
- Chronic granulocytic leukaemia [MedDRA LLT]
- Chronic granulocytic leukemia [MedDRA LLT]
- Chronic myelocytic leukaemia [MedDRA LLT]
- Chronic myelocytic leukemia [MedDRA LLT]
- Chronic myelogenous leukaemia [MedDRA LLT]
- Chronic myelogenous leukaemia, BCR-ABL1-positive [ICD-11 Subcategory]
- Chronic myelogenous leukemia [PASCAL descriptor]
- Chronic myelogenous leukemia [HPO term]
- Chronic myelogenous leukemia [MedDRA LLT]
- Chronic myelogenous leukemia, BCR/ABL positive [ICD-O code]
- Chronic myelogenous leukemia, BCR/ABL positive (morphologic abnormality) [Inactive SNOMED CT concept]
- Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Chronic myeloid leukaemia [ICD-10 Sub-category (who)]
- Chronic myeloid leukaemia [MedDRA Preferred Term]
- Chronic myeloid leukemia [ICD-9 code]
- Chronic myeloid leukemia [MedDRA LLT]
- Chronic myeloid leukemia (disorder) [SNOMED CT concept]
- Chronic myeloid leukemia, BCR/ABL-positive [ICD-10 Sub-category]
- Chronic myeloid leukemia, NOS [ICD-O code]
- Leukaemia myelocytic chronic [MedDRA LLT]
- Leukaemias chronic myeloid [MedDRA High Level Term]
- Leukemia myelocytic chronic [MedDRA LLT]
- Leukemia, chronic myeloid [OMIM Phenotype]
- Myeloid leukaemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [ICD-9 code]
- Myeloid leukemia, chronic [MedDRA LLT]
- chronic myeloid leukemia [DO Concept]
- chronic myeloid leukemia [MedlinePlus Topic]
- chronic myeloid leukemia [SNOMED Notion]
- leukemia, myelogenous, chronic, BCR-ABL positive [MeSH concept]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
- myeloid leukemia [Blood Transfusion thesaurus concept]
DO Cross reference
- chronic myeloid leukemia [DO Concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
False automatic mappings
- Chronic myeloid leukaemia (in remission) [MedDRA Preferred Term]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- CML [MedDRA LLT]
- Chronic granulocytic leukaemia [MedDRA LLT]
- Chronic granulocytic leukemia [MedDRA LLT]
- Chronic myelocytic leukaemia [MedDRA LLT]
- Chronic myelocytic leukemia [MedDRA LLT]
- Chronic myelogenous leukaemia [MedDRA LLT]
- Chronic myelogenous leukemia [MedDRA LLT]
- Chronic myelogenous leukemia [HPO term]
- Chronic myelogenous leukemia [PASCAL descriptor]
- Chronic myelogenous leukemia, BCR/ABL positive [ICD-O code]
- Chronic myelogenous leukemia, BCR/ABL positive (morphologic abnormality) [Inactive SNOMED CT concept]
- Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Chronic myeloid leukaemia [MedDRA Preferred Term]
- Chronic myeloid leukaemia [ICD-10 Sub-category (who)]
- Chronic myeloid leukemia [ORDO Disease]
- Chronic myeloid leukemia [MedDRA LLT]
- Chronic myeloid leukemia (disorder) [SNOMED CT concept]
- Chronic myeloid leukemia, NOS [ICD-O code]
- Leukaemia myelocytic chronic [MedDRA LLT]
- Leukaemias chronic myeloid [MedDRA High Level Term]
- Leukemia myelocytic chronic [MedDRA LLT]
- Leukemia, chronic myeloid [OMIM Phenotype]
- Myeloid leukaemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [ICD-9 code]
- chronic myeloid leukemia [DO Concept]
- chronic myeloid leukemia [Disease (Nov.)]
- chronic myeloid leukemia [MedlinePlus Topic]
- chronic myeloid leukemia [SNOMED Notion]
- leukemia, myelogenous, chronic, BCR-ABL positive [MeSH concept]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
Validated automatic mappings to NTBT
- Chronic myeloid leukemia [ORDO Disease]
- chronic myeloid leukemia [Disease (Nov.)]
associated_with_malfunction_of_gene_product
- Breakpoint Cluster Region Protein [NCIt concept]
- LIM/Homeobox Protein Lhx2 [NCIt concept]
- Platelet-Derived Growth Factor Receptor Beta [NCIt concept]
- Zinc Finger Protein Gfi-1b [NCIt concept]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- CTS-API Disease Main Type Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Clinical Trials Search-Application Programming Interface Disease Category Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_excludes_molecular_abnormality
- FGFR1 Gene Rearrangement [NCIt concept]
- PDGFRA Gene Rearrangement [NCIt concept]
- PDGFRB Gene Rearrangement [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_associated_gene
- GFI1B Gene [NCIt concept]
- GFI1B wt Allele [NCIt concept]
- LHX2 Gene [NCIt concept]
- LHX2 wt Allele [NCIt concept]
- MIR10A Gene [NCIt concept]
- MIR10A wt Allele [NCIt concept]
- MIR15A Gene [NCIt concept]
- MIR15A wt Allele [NCIt concept]
- MIR203A Gene [NCIt concept]
- MIR203A wt Allele [NCIt concept]
- MIR223 Gene [NCIt concept]
- MIR223 wt Allele [NCIt concept]
- Oncogene ABL1 [NCIt concept]
disease_has_finding
- Hypercellular Bone Marrow [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Splenomegaly [NCIt concept]
disease_has_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Pluripotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- ABL1 Gene [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- ABL1 Gene [NCIt concept]
- ABL1 wt Allele [NCIt concept]
- BCR/ABL1 Fusion Gene [NCIt concept]
- BCR/ABL1 Fusion Gene p190 [NCIt concept]
- BCR/ABL1 Fusion Gene p210 [NCIt concept]
- BCR/ABL1 Fusion Gene p230 [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.1052T>C Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.1075T>G Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.1150C>A Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.1187A>C Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.1187A>G Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.1457T>C Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.742C>G Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.749G>A Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.756G>C Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.756G>T Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.758A>T Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.763G>A Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.764A>T Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.827A>G Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.835G>A Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.895G>C Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.895G>T Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.944C>T Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.949T>C Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.951C>A Mutation [NCIt concept]
- BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.951C>G Mutation [NCIt concept]

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