BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.764A T Mutation - CISMeF
BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.764A T MutationNCIt concept
Preferred Label : BCR/ABL1 Fusion Gene with ABL1 NM_005157.4:c.764A T Mutation;
NCIt synonyms : BCR/ABL1 Fusion Gene with ABL1 NM_005157.5:c.764A T; BCR/ABL1 Fusion Gene with NM_005157.4:c.764A T; BCR/ABL Fusion Gene with NM_005157.5:c.764A T; BCR/ABL Fusion Gene with NM_005157.4:c.764A T; BCR::ABL1 Fusion Gene with ABL1 NM_005157.4:c.764A T Mutation;
NCIt definition : A fusion gene that results from a translocation t(9;22)(q34;q11) that fuses the 5'
part of the BCR gene to the 5' side of exon 2 of a mutated form of the ABL1 gene.
In this fusion gene there is a point mutation where adenine has been substituted with
thymine at nucleotide position 764 of the ABL1 gene. This mutation is associated with
imatinib- and nilotinib-resistant leukemias.;
NCIt note : The position of the point mutation is denoted by its location in the ABL1 cDNA sequence
(NCBI Reference Sequence: NM_005157.4) and not its location in the fusion gene cDNA.;