Oncogene ABL1 - CISMeF

Preferred Label : Oncogene ABL1;

NCIt synonyms : Abelson Murine Leukemia Viral Oncogene Homolog; ABL; Oncogene, ABL; Oncogene, ABL1; v-ABL;

NCIt definition : Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1 protein. Alternative splicing of this gene produces two protein isoforms. A t(9;22) translocation, resulting in the fusion of the BCR and ABL1 genes, has been detected in many cases of chronic myelogeneous leukemia.. This BCR-ABL fusion gene is also present in acute myeloid leukemia and acute lymphoblastic leukemia.;

NCI Metathesaurus CUI : CL415411;

Details

Origin ID

C17397;

UMLS CUI

C5441597;

Currated CISMeF NLP mapping
- abl oncogene [MeSH concept]
OMIM relation
- Abl protooncogene 1, nonreceptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- abl oncogene [MeSH concept]
gene_associated_with_disease
- Acute Lymphoblastic Leukemia [NCIt concept]
- Acute Myeloid Leukemia [NCIt concept]
- Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 9q34.1 [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Division Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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