" /> Zinc Finger Protein Gfi-1b - CISMeF





Preferred Label : Zinc Finger Protein Gfi-1b;

NCIt synonyms : Growth Factor Independent Protein 1B; Potential Regulator of CDKN1A Translocated in CML; GFI1B; GF11B Protein; Growth Factor Independence-1B; Growth Factor Independence-1B Protein;

NCIt definition : Zinc finger protein Gfi-1b (330 aa, 37 kDa) is encoded by the human GFI1B gene. This protein is involved in both transcriptional regulation and cell proliferation.;

NCIt note : Growth Factor Independence-1B, encoded by the human GFI1B gene, is a zinc finger protein. This protein is a transcription factor with specific involvement in the regulation of erythroid cell growth in normal erythropoiesis through modulating erythroid-specific gene expression. The function of GFI1B to modulate transcription depends on promoter context. Human GFI1B expression by Northern blot analysis is highest in bone marrow and fetal liver as well as in the chronic myeloid leukemia cell line K562 with lower levels in other hematopoietic precursor cells. Expression of GFI1B is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Its expression does not promote erythroid commitment, but enhances proliferation of immature erythroblasts. The chromosomal region of this gene is translocated to chromosome 22q11 in chronic myeloid leukemia. (OMIM, PubMed 12351384);

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12/05/2024


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