Breakpoint Cluster Region Protein

Preferred Label : Breakpoint Cluster Region Protein;

NCIt synonyms : BCR Protein; BCR1; D22S662; BCR; CML; D22S11; PHL; ALL; EC 2.7.11.1; Renal Carcinoma Antigen NY-REN-26;

NCIt definition : Breakpoint cluster region protein (1271 aa, 143 kDa) is encoded by the human BCR gene. This protein is involved in both serine/threonine-protein kinase and GTPase-activating protein activities.;

NCIt note : Breakpoint cluster region protein is a GTPase-activating protein for the small GTPases Ras-related C3 botulinum toxin substrate 1 and cell division control protein 42 homolog. (UniProt);

Details

Origin ID

C17477;

UMLS CUI

C0105421;

False automatic mappings
- All [HPO term]
- All members of set (qualifier value) [SNOMED CT concept]
- Chronic myeloid leukemia [ORDO Disease]
- GO top tree [GO term]
- Universal restriction modifier (core metadata concept) [SNOMED CT concept]
- all [Radlex concept]
OMIM relation
- Bcr activator of rhogef and gtpase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- BCR protein, human [MeSH concept]
- BCR protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- BCR Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Lymphoblastic Leukemia [NCIt concept]
- Chronic Myeloid Leukemia, BCR-ABL1 Positive [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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