Post-Translational Modification

Preferred Label : Post-Translational Modification;

NCIt synonyms : Post Translational Modification; Protein Modification; Protein/Amino Acid Biochemistry, Post-Translational Modification; Post-Translational Modification Alteration; Posttranslational Modification;

NCIt definition : The enzymatic processing of a polypeptide chain after translation from messenger RNA and after peptide bond formation has occurred. Examples include glycosylation, acylation, limited proteolysis, phosphorylation, isoprenylation.;

Details

Origin ID

C17019;

UMLS CUI

C0033666;

Automatic exact mappings (from CISMeF team)
- Protein modification ID [EDAM data]
- Protein modifications [EDAM topic]
Currated CISMeF NLP mapping
- Post-translational modification [OMIConto structure]
- post-translational protein modification [GO term]
- protein processing, Post-Translational [MeSH concept]
- protein processing, post-translational [MeSH Descriptor]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- Post-translational modification [OMIConto index]
- Post-translational modification [OMIConto structure]
- Protein post-translational modifications [EDAM topic]
- post-translational protein modification [GO term]
- protein processing [GO term]
- protein processing, Post-Translational [MeSH concept]
- protein processing, post-translational [MeSH Descriptor]
biological_process_involves_gene_product
- A-Kinase Anchor Protein 13 [NCIt concept]
- ARHGEF5 Gene Product [NCIt concept]
- Aspartyl/Asparaginyl Beta-Hydroxylase [NCIt concept]
- BLOC-3 Complex Member HPS1 [NCIt concept]
- Bifunctional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase [NCIt concept]
- Biglycan [NCIt concept]
- Biotin-Protein Ligase [NCIt concept]
- Breakpoint Cluster Region Protein [NCIt concept]
- DCN1-Like Protein 1 [NCIt concept]
- DENN Domain-Containing Protein 3 [NCIt concept]
- Dedicator of Cytokinesis Protein 2 [NCIt concept]
- Dedicator of Cytokinesis Protein 8 [NCIt concept]
- Deoxyhypusine Synthase [NCIt concept]
- Dolichol-Phosphate Mannosyltransferase Subunit 1 [NCIt concept]
- E3 ISG15-Protein Ligase HERC5 [NCIt concept]
- E3 SUMO-Protein Ligase CBX4 [NCIt concept]
- E3 SUMO-Protein Ligase EGR2 [NCIt concept]
- E3 SUMO-Protein Ligase NSE2 [NCIt concept]
- E3 SUMO-Protein Ligase PIAS1 [NCIt concept]
- E3 SUMO-Protein Ligase PIAS3 [NCIt concept]
- E3 SUMO-Protein Ligase RanBP2 [NCIt concept]
- E3 SUMO-Protein Ligase ZNF451 [NCIt concept]
- ERO1-Like Protein Alpha [NCIt concept]
- FYVE, RhoGEF and PH Domain-Containing Protein 1 [NCIt concept]
- FYVE, RhoGEF and PH Domain-Containing Protein 4 [NCIt concept]
- FYVE, RhoGEF and PH Domain-Containing Protein 5 [NCIt concept]
- Furin [NCIt concept]
- Geranylgeranyl Transferase [NCIt concept]
- Geranylgeranyl Transferase Type-1 Subunit Beta [NCIt concept]
- Glutaminyl-Peptide Cyclotransferase [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Guanine Nucleotide Exchange Factor C9orf72 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV3 [NCIt concept]
- IQ Motif and SEC7 Domain-Containing Protein 1 [NCIt concept]
- IQ Motif and SEC7 Domain-Containing Protein 2 [NCIt concept]
- Kalirin [NCIt concept]
- Lipase Maturation Factor 1 [NCIt concept]
- Lysyl Oxidase Homolog 1 [NCIt concept]
- Lysyl Oxidase Homolog 2 [NCIt concept]
- MAP Kinase-Activating Death Domain Protein [NCIt concept]
- Mannose-P-Dolichol Utilization Defect 1 Protein [NCIt concept]
- Methyl-CpG-Binding Domain Protein 3 [NCIt concept]
- NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial [NCIt concept]
- NAD-Dependent Protein Deacylase Sirtuin-6 [NCIt concept]
- NEDD8 [NCIt concept]
- NEDD8-Activating Enzyme E1 Catalytic Subunit [NCIt concept]
- NEDD8-Activating Enzyme E1 Regulatory Subunit [NCIt concept]
- Obscurin [NCIt concept]
- Oncogene TIM Protein [NCIt concept]
- Palmitoyl-Protein Thioesterase 1 [NCIt concept]
- Palmitoyltransferase ZDHHC2 [NCIt concept]
- Palmitoyltransferase ZDHHC20 [NCIt concept]
- Palmitoyltransferase ZDHHC8 [NCIt concept]
- Palmitoyltransferase ZDHHC9 [NCIt concept]
- Peptidyl-Prolyl Cis-Trans Isomerase B [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein [NCIt concept]
- Phosphatidylinositol Glycan Anchor Biosynthesis Class U Protein [NCIt concept]
- Pleckstrin Homology Domain-Containing Family G Member 5 [NCIt concept]
- Post-GPI Attachment to Proteins Factor 2 [NCIt concept]
- Prelamin-A/C [NCIt concept]
- Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2 [NCIt concept]
- Prolyl 4-Hydroxylase Subunit Alpha-2 [NCIt concept]
- Protein Disulfide-Isomerase A3 [NCIt concept]
- Protein ECT2 [NCIt concept]
- Protein O-GlcNAcase [NCIt concept]
- Protein PML [NCIt concept]
- Protein-Arginine Deiminase Type-2 [NCIt concept]
- Protein-Arginine Deiminase Type-4 [NCIt concept]
- Protein-Glutamine Gamma-Glutamyltransferase 2 [NCIt concept]
- Protein-Glutamine Gamma-Glutamyltransferase Z [NCIt concept]
- Protein-Serine O-Palmitoleoyltransferase Porcupine [NCIt concept]
- Proto-Oncogene DBL [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RAS Guanyl-Releasing Protein 1 [NCIt concept]
- Ragulator Complex Protein LAMTOR5 [NCIt concept]
- Ral Guanine Nucleotide Dissociation Stimulator [NCIt concept]
- Ral-GDS-Related Protein [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor-Like 1 [NCIt concept]
- Rap1 GTPase-GDP Dissociation Stimulator 1 [NCIt concept]
- Ras-Specific Guanine Nucleotide-Releasing Factor 1 [NCIt concept]
- Ras-Specific Guanine Nucleotide-Releasing Factor 2 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 10 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 10-Like Protein [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 12 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 28 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 5 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 7 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor TIAM2 [NCIt concept]
- SUMO-Activating Enzyme Subunit 1 [NCIt concept]
- SUMO-Activating Enzyme Subunit 2 [NCIt concept]
- SUMO-Conjugating Enzyme UBC9 [NCIt concept]
- Sentrin-Specific Protease 1 [NCIt concept]
- Sentrin-Specific Protease 6 [NCIt concept]
- Serine Palmitoyltransferase 1 [NCIt concept]
- Small Ubiquitin-Related Modifier 1 [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Sonic Hedgehog Protein [NCIt concept]
- Sulfatase-Modifying Factor 1 [NCIt concept]
- Sulfhydryl Oxidase 1 [NCIt concept]
- Sulfhydryl Oxidase 2 [NCIt concept]
- Suppression of Tumorigenicity 5 Protein Isoform 2 [NCIt concept]
- Suppressor of Tumorigenicity 14 Protein [NCIt concept]
- T-Lymphoma Invasion and Metastasis-Inducing Protein 1 [NCIt concept]
- Transcriptional Intermediary Factor 1-Beta [NCIt concept]
- Transglutaminase [NCIt concept]
- Triple Functional Domain Protein [NCIt concept]
- Tubulin-Tyrosine Ligase [NCIt concept]
- Ubiquitin-Like Modifier-Activating Enzyme 1 [NCIt concept]
biological_process_is_part_of_process
- Post-Translational Regulation [NCIt concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
process_involves_gene
- ASPH Gene [NCIt concept]
- ASPH wt Allele [NCIt concept]
- BGN Gene [NCIt concept]
- BGN wt Allele [NCIt concept]
- CBX4 Gene [NCIt concept]
- CBX4 wt Allele [NCIt concept]
- DHPS Gene [NCIt concept]
- DHPS wt Allele [NCIt concept]
- DPM1 Gene [NCIt concept]
- DPM1 wt Allele [NCIt concept]
- EGR2 Gene [NCIt concept]
- EGR2 wt Allele [NCIt concept]
- ERO1A Gene [NCIt concept]
- ERO1A wt Allele [NCIt concept]
- FURIN Gene [NCIt concept]
- FURIN wt Allele [NCIt concept]
- GNE Gene [NCIt concept]
- GNE wt Allele [NCIt concept]
- HERC5 Gene [NCIt concept]
- HERC5 wt Allele [NCIt concept]
- HLA-DMA Gene [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB Gene [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLCS Gene [NCIt concept]
- HLCS wt Allele [NCIt concept]
- LCAT Gene [NCIt concept]
- LCAT wt Allele [NCIt concept]
- LMF1 Gene [NCIt concept]
- LMF1 wt Allele [NCIt concept]
- LOXL1 Gene [NCIt concept]
- LOXL1 wt Allele [NCIt concept]
- LOXL2 Gene [NCIt concept]
- LOXL2 wt Allele [NCIt concept]
- MBD3 Gene [NCIt concept]
- MBD3 wt Allele [NCIt concept]
- MPDU1 Gene [NCIt concept]
- MPDU1 wt Allele [NCIt concept]
- NAE1 Gene [NCIt concept]
- NAE1 wt Allele [NCIt concept]
- NEDD8 Gene [NCIt concept]
- NEDD8 wt Allele [NCIt concept]
- NSMCE2 Gene [NCIt concept]
- NSMCE2 wt Allele [NCIt concept]
- OGA Gene [NCIt concept]
- OGA wt Allele [NCIt concept]
- P4HA2 Gene [NCIt concept]
- P4HA2 wt Allele [NCIt concept]
- PADI2 Gene [NCIt concept]
- PADI2 wt Allele [NCIt concept]
- PADI4 Gene [NCIt concept]
- PADI4 wt Allele [NCIt concept]
- PDIA3 Gene [NCIt concept]
- PDIA3 wt Allele [NCIt concept]
- PGAP2 Gene [NCIt concept]
- PGAP2 wt Allele [NCIt concept]
- PGGT1B Gene [NCIt concept]
- PGGT1B wt Allele [NCIt concept]
- PIAS1 Gene [NCIt concept]
- PIAS1 wt Allele [NCIt concept]
- PIAS3 Gene [NCIt concept]
- PIAS3 wt Allele [NCIt concept]
- PIGU Gene [NCIt concept]
- PIGU wt Allele [NCIt concept]
- PLOD2 Gene [NCIt concept]
- PLOD2 wt Allele [NCIt concept]
- PML Gene [NCIt concept]
- PML wt Allele [NCIt concept]
- PORCN Gene [NCIt concept]
- PORCN wt Allele [NCIt concept]
- PPIB Gene [NCIt concept]
- PPIB wt Allele [NCIt concept]
- PPT1 Gene [NCIt concept]
- PPT1 wt Allele [NCIt concept]
- QPCT Gene [NCIt concept]
- QPCT wt Allele [NCIt concept]
- QSOX1 Gene [NCIt concept]
- QSOX1 wt Allele [NCIt concept]
- QSOX2 Gene [NCIt concept]
- QSOX2 wt Allele [NCIt concept]
- RANBP2 Gene [NCIt concept]
- RANBP2 wt Allele [NCIt concept]
- SAE1 Gene [NCIt concept]
- SAE1 wt Allele [NCIt concept]
- SENP1 Gene [NCIt concept]
- SENP1 wt Allele [NCIt concept]
- SENP6 Gene [NCIt concept]
- SENP6 wt Allele [NCIt concept]
- SHH Gene [NCIt concept]
- SHH wt Allele [NCIt concept]
- SIRT3 Gene [NCIt concept]
- SIRT3 wt Allele [NCIt concept]
- SIRT6 Gene [NCIt concept]
- SIRT6 wt Allele [NCIt concept]
- SUMF1 Gene [NCIt concept]
- SUMF1 wt Allele [NCIt concept]
- SUMO1 Gene [NCIt concept]
- SUMO1 wt Allele [NCIt concept]
- TGM2 Gene [NCIt concept]
- TGM2 wt Allele [NCIt concept]
- TGM7 Gene [NCIt concept]
- TGM7 wt Allele [NCIt concept]
- TRIM28 Gene [NCIt concept]
- TRIM28 wt Allele [NCIt concept]
- TTL Gene [NCIt concept]
- TTL wt Allele [NCIt concept]
- UBA1 Gene [NCIt concept]
- UBA1 wt Allele [NCIt concept]
- UBA2 Gene [NCIt concept]
- UBA2 wt Allele [NCIt concept]
- UBA3 Gene [NCIt concept]
- UBA3 wt Allele [NCIt concept]
- UBE2I Gene [NCIt concept]
- UBE2I wt Allele [NCIt concept]
- ZDHHC2 Gene [NCIt concept]
- ZDHHC2 wt Allele [NCIt concept]
- ZDHHC20 Gene [NCIt concept]
- ZDHHC20 wt Allele [NCIt concept]
- ZDHHC8 Gene [NCIt concept]
- ZDHHC8 wt Allele [NCIt concept]
- ZDHHC9 Gene [NCIt concept]
- ZDHHC9 wt Allele [NCIt concept]
- ZNF451 Gene [NCIt concept]
- ZNF451 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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