Rho Guanine Nucleotide Exchange Factor 12

Preferred Label : Rho Guanine Nucleotide Exchange Factor 12;

NCIt synonyms : ARHGEF12; Leukemia-Associated RhoGEF;

NCIt definition : Rho guanine nucleotide exchange factor 12 (1544 aa, 173 kDa) is encoded by the human ARHGEF12 gene. This protein plays a role in the regulation of Rho-family GTPase- and G-protein coupled receptor-mediated signal transduction.;

Details

Origin ID

C97438;

UMLS CUI

C3275242;

OMIM relation
- Rho guanine nucleotide exchange factor 12 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ARHGEF12 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- DH Domain [NCIt concept]
- PDZ Domain [NCIt concept]
- PH Domain [NCIt concept]
- RGS Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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