RGS Domain - CISMeF

Preferred Label : RGS Domain;

NCIt synonyms : RGS-Signaling Domain; Regulators of G Protein Signaling Domain;

NCIt definition : Typically 120 amino acids long, the RGS (Regulator of G protein Signaling) Domain is found in over 20 human proteins, bind activated G-alpha subunits, and are responsible for GAP function. Through other domains (e.g., DEP, PDZ, or PH) RGS proteins link to other signaling molecules. RGS domains contain conserved contiguous, or dispersed, GH subdomains (GH1, 2, and 3). All RGS domains share a tertiary structure of nine alpha helixes that form a right-handed anti-parallel bundle of helixes 4-7 and a terminal bundle of helixes 1-3 and 8-9. The 3-4, 5-6, and 7-8 helix loops form an interaction surface between RGS4 and Ga(i). RGS domains allosterically stabilize the G-alpha GTP binding pocket, accelerating GTPase activity. Thus, RGS Family members rapidly inactivate G protein signal transmission from seven transmembrane receptors in GPCR signaling pathways. (NCI);

Details

Origin ID

C14107;

UMLS CUI

C1514648;

Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
is_structural_domain_or_motif_of_gene_product
- A-Kinase Anchor Protein 10, Mitochondrial [NCIt concept]
- Axin-1 [NCIt concept]
- Axin-2 [NCIt concept]
- Beta-Adrenergic Receptor Kinase 1 [NCIt concept]
- Beta-Adrenergic Receptor Kinase 2 [NCIt concept]
- G Protein-Coupled Receptor Kinase [NCIt concept]
- G Protein-Coupled Receptor Kinase 4 [NCIt concept]
- G Protein-Coupled Receptor Kinase 5 [NCIt concept]
- G Protein-Coupled Receptor Kinase 6 [NCIt concept]
- G Protein-Coupled Receptor Kinase 7 [NCIt concept]
- RGS Family Protein [NCIt concept]
- Regulator of G-Protein Signaling 1 [NCIt concept]
- Regulator of G-Protein Signaling 16 [NCIt concept]
- Regulator of G-Protein Signaling 19 [NCIt concept]
- Regulator of G-Protein Signaling 2 [NCIt concept]
- Regulator of G-Protein Signaling 22 [NCIt concept]
- Regulator of G-Protein Signaling 3 [NCIt concept]
- Regulator of G-Protein Signaling 4 [NCIt concept]
- Regulator of G-Protein Signaling 5 [NCIt concept]
- Regulator of G-Protein Signaling 7 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 12 [NCIt concept]
- Rhodopsin Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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