Beta-Adrenergic Receptor Kinase 1

Preferred Label : Beta-Adrenergic Receptor Kinase 1;

NCIt synonyms : BETA-ARK1; GRK2; EC 2.7.1.126; Beta-ARK-1; BARK1; G-Protein Coupled Receptor Kinase 2; ADRBK1; EC 2.7.11.15; Beta Adrenergic Receptor Kinase-1; Adrenergic Beta Receptor Kinase 1; G Protein-Dependent Receptor Kinase 2;

NCIt definition : Beta-adrenergic receptor kinase 1 (689 aa, 80 kDa) is encoded by the human GRK2 gene. This protein is involved in both G protein-coupled receptor signaling and muscle contraction.;

Details

Origin ID

C21382;

UMLS CUI

C1505681;

Currated CISMeF NLP mapping
- G-Protein-Coupled receptor kinase 2 [MeSH Descriptor]
- G-Protein-Coupled receptor kinase 2 [MeSH concept]
OMIM relation
- G protein-coupled receptor kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- G-Protein-Coupled receptor kinase 2 [MeSH concept]
- G-Protein-Coupled receptor kinase 2 [MeSH Descriptor]
- GRK2 protein, human [MeSH Supplementary Concept]
- GRK2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- G Protein-Coupled Receptor Kinase Gene [NCIt concept]
- GRK2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- PH Domain [NCIt concept]
- RGS Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- GPCR Desensitization Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
- HDAC Class II Signaling Pathway [NCIt concept]
- MAP Kinase Activation Pathway [NCIt concept]
- Thromboxane A2 Receptor Family Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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