GPCR Signaling Pathway

Preferred Label : GPCR Signaling Pathway;

NCIt related terms : Roles of beta-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling;

Alternative definition : BIOCARTA: The binding of b-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK), to the receptor-b-arrestin complex. Several signaling events have been reported to involve b-arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent beta2-adrenergic receptor endocytosis by tyrosine phosphorylation of dynamin, Ras-dependent activation of the ERK1/2 MAP kinase cascade and stimulation of cell proliferation by beta2-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_bArrestin-srcPathway;

Details

Origin ID

C39001;

UMLS CUI

C1517369;

Automatic exact mappings (from CISMeF team)
- G protein-coupled receptor signaling pathway [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- G protein-coupled receptor signaling pathway [GO term]
has_gene_product_element
- Beta-Adrenergic Receptor Kinase 1 [NCIt concept]
- Beta-Arrestin-1 [NCIt concept]
- Beta-Arrestin-2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- GTPase HRas [NCIt concept]
- Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short [NCIt concept]
- Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms XLas [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Tyrosine-Protein Kinase Fgr [NCIt concept]
- Tyrosine-Protein Kinase Hck [NCIt concept]
pathway_has_gene_element
- ARRB1 wt Allele [NCIt concept]
- ARRB2 wt Allele [NCIt concept]
- FGR wt Allele [NCIt concept]
- GNAS wt Allele [NCIt concept]
- GRK2 wt Allele [NCIt concept]
- HCK wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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