Mitogen-Activated Protein Kinase 1

Preferred Label : Mitogen-Activated Protein Kinase 1;

NCIt synonyms : p42MAPK; Extracellular Signal-Regulated Kinase 2; MAP Kinase 1; MAPK1; PRKM1; MAP Kinase Isoform p42; MAPK 2; MAP Kinase 2; Mitogen-Activated Protein Kinase 2; EC 2.7.11.24; ERK-2; p42-MAPK; ERT1; MAPK 1; Mitogen-Activated Protein Kinase-1;

NCIt definition : Mitogen-activated protein kinase 1 (390 aa, 41 kDa) is encoded by the human MAPK1 gene. This protein plays a role in cell cycle regulation, signal transduction, transcriptional regulation and serine/threonine phosphorylation.;

NCIt note : When MAPK1 is autophosphorylated or phosphorylated/activated by upstream kinases on threonine and tyrosine residues, it forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors.;

Details

Origin ID

C17589;

UMLS CUI

C2713871;

Automatic exact mappings (from CISMeF team)
- MAP kinase activity [GO term]
- Mitogen-Activated protein kinase 7 [MeSH Descriptor]
- mitogen-activated protein kinase 1 [ORDO Gene]
OMIM relation
- Mitogen-activated protein kinase 1 [OMIM gene]
See also inter- (CISMeF)
- Mitogen-activated protein kinase 1 [OMIM gene]
- mitogen-activated protein kinase 1 [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAPK1 protein, human [MeSH Supplementary Concept]
- MAPK1 protein, human [MeSH concept]
Validated automatic mappings to NTBT
- Mitogen-Activated protein kinase 1 [MeSH Descriptor]
- Mitogen-Activated protein kinase 1 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP Kinase Gene [NCIt concept]
- MAPK1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_gene_product_variant
- MAPK1 NP_002736.3:p.E322K [NCIt concept]
- MAPK1 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- Agrin Pathway [NCIt concept]
- Aldosterone-Regulated Sodium Reabsorption Pathway [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BAD Regulation Pathway [NCIt concept]
- BMP Receptor Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- CCR3 Signaling Pathway [NCIt concept]
- CREB Activation Signaling Pathway [NCIt concept]
- CXCR4 Signaling Pathway [NCIt concept]
- Cadmium Induction Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Dorso-Ventral Axis Formation Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Formyl Peptide Receptor 1 Signaling Pathway [NCIt concept]
- G1 to S Transition Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- IGF1R Antiapoptosis Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- MAP Kinase Activation Pathway [NCIt concept]
- MAP Kinase Downregulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Neuronal Survival Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Nongenotropic Androgen Signaling Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Papillary Thyroid Carcinoma Pathway [NCIt concept]
- Pelp1 Estrogen Receptor Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Splicing Regulation Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
- eIF4 Regulation Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Beroterkib Anhydrous [NCIt concept]
- ERK Inhibitor [NCIt concept]
- ERK1/2 Inhibitor D3S-002 [NCIt concept]
- ERK1/2 Inhibitor ERAS-007 [NCIt concept]
- ERK1/2 Inhibitor HH2710 [NCIt concept]
- ERK1/2 Inhibitor JSI-1187 [NCIt concept]
- ERK1/2 Inhibitor KO-947 [NCIt concept]
- ERK1/2 Inhibitor UCT-01-097 [NCIt concept]
- Ravoxertinib [NCIt concept]
- Rineterkib [NCIt concept]
- Temuterkib [NCIt concept]
- Temuterkib Mesylate [NCIt concept]
- Ulixertinib [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients