Tyrosine-Protein Kinase Hck

Preferred Label : Tyrosine-Protein Kinase Hck;

NCIt synonyms : B-cell/myeloid kinase; Hemopoietic Cell Kinase p60; p59-HCK; p59-HCK/p60-HCK; HCK; Hematopoietic Cell Kinase; p59Hck; p61Hck; Hemopoietic Cell Kinase p59; EC 2.7.10.2; p60-HCK;

NCIt definition : Tyrosine-protein kinase Hck (526 aa, 60 kDa) is encoded by the human HCK gene. This protein plays a role in tyrosine phosphorylation, signaling and the regulation of innate immunity.;

NCIt note : p60-HCK and p59-HCK are produced by alternative initiation from the same proto-oncongene HCK.;

Details

Origin ID

C18558;

UMLS CUI

C0084219;

Automatic exact mappings (from CISMeF team)
- Hck protooncogene, src family tyrosine kinase [OMIM gene]
- proto-oncogene proteins c-hck [MeSH Descriptor]
OMIM relation
- Hck protooncogene, src family tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HCK protein, human [MeSH concept]
- HCK protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HCK Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- SRC Family Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- B-Lymphocyte [NCIt concept]
- Granulocyte [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
- HIV-1 Infection Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Rebastinib [NCIt concept]
- Rebastinib Tosylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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