Fc Gamma Receptor-Mediated Phagocytosis Pathway

Preferred Label : Fc Gamma Receptor-Mediated Phagocytosis Pathway;

NCIt related terms : Fc gamma R-mediated phagocytosis;

Alternative definition : KEGG: Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsinization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.;

KEGG ID : hsa04666;

Details

Origin ID

C91499;

UMLS CUI

C2984309;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 [NCIt concept]
- 85 kDa Calcium-Independent Phospholipase A2 [NCIt concept]
- ADP-Ribosylation Factor 6 [NCIt concept]
- Actin Nucleation-Promoting Factor WAS [NCIt concept]
- Actin-Binding Protein WASF2 [NCIt concept]
- Actin-Binding Protein WASF3 [NCIt concept]
- Actin-Related Protein 2/3 Complex Subunit 1B [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- Arf-GAP with SH3 Domain, Ankyrin Repeat and PH Domain-Containing 1 [NCIt concept]
- Cofilin-1 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Cytosolic Phospholipase A2 [NCIt concept]
- Cytosolic Phospholipase A2 Beta [NCIt concept]
- Cytosolic Phospholipase A2 Delta [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dynamin-2 [NCIt concept]
- GRB2-Associated-Binding Protein 2 [NCIt concept]
- Gelsolin [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV3 [NCIt concept]
- High Affinity Immunoglobulin Gamma Fc Receptor I [NCIt concept]
- LIM Domain Kinase 1 [NCIt concept]
- LIM Domain Kinase 2 [NCIt concept]
- Linker for Activation of T-Cells Family Member 1 [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor II-A [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B [NCIt concept]
- MYC Box-Dependent-Interacting Protein 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Neural Wiskott-Aldrich Syndrome Protein [NCIt concept]
- Neutrophil Cytosol Factor 1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 2 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Alpha [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Phospholipid Phosphatase 1 [NCIt concept]
- Phospholipid Phosphatase 3 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Kinase C Delta Type [NCIt concept]
- Protein Kinase C Epsilon Type [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase C [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-2 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Sphingosine Kinase 1 [NCIt concept]
- Sphingosine Kinase 2 [NCIt concept]
- Tyrosine-Protein Kinase Hck [NCIt concept]
- Tyrosine-Protein Kinase Lyn [NCIt concept]
- Tyrosine-Protein Kinase SYK [NCIt concept]
- Vasodilator-Stimulated Phosphoprotein [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARF6 wt Allele [NCIt concept]
- ARPC1B wt Allele [NCIt concept]
- ASAP1 wt Allele [NCIt concept]
- BIN1 wt Allele [NCIt concept]
- CFL1 wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- DNM2 wt Allele [NCIt concept]
- FCGR1A wt Allele [NCIt concept]
- FCGR2A wt Allele [NCIt concept]
- FCGR2B wt Allele [NCIt concept]
- FCGR3A wt Allele [NCIt concept]
- FCGR3B wt Allele [NCIt concept]
- GAB2 wt Allele [NCIt concept]
- GSN wt Allele [NCIt concept]
- HCK wt Allele [NCIt concept]
- INPP5D wt Allele [NCIt concept]
- INPPL1 wt Allele [NCIt concept]
- LAT wt Allele [NCIt concept]
- LIMK2 wt Allele [NCIt concept]
- LYN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NCF1 wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PIP5K1A wt Allele [NCIt concept]
- PLA2G4A wt Allele [NCIt concept]
- PLA2G4B wt Allele [NCIt concept]
- PLA2G4D wt Allele [NCIt concept]
- PLA2G6 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PLCG2 wt Allele [NCIt concept]
- PLPP1 wt Allele [NCIt concept]
- PLPP3 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PRKCD wt Allele [NCIt concept]
- PRKCE wt Allele [NCIt concept]
- PTPRC wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RPS6KB2 wt Allele [NCIt concept]
- SPHK1 wt Allele [NCIt concept]
- SPHK2 wt Allele [NCIt concept]
- SYK wt Allele [NCIt concept]
- VASP wt Allele [NCIt concept]
- VAV1 wt Allele [NCIt concept]
- VAV2 wt Allele [NCIt concept]
- VAV3 wt Allele [NCIt concept]
- WAS wt Allele [NCIt concept]
- WASF2 wt Allele [NCIt concept]
- WASF3 wt Allele [NCIt concept]
- WASL wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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