Sphingosine Kinase 1

Preferred Label : Sphingosine Kinase 1;

NCIt synonyms : EC 2.7.1.91; SK 1; SPK 1; SPHK1;

NCIt definition : Sphingosine kinase 1 (384 aa, 43 kDa) is encoded by the human SPHK1 gene. This protein plays a role in the phosphorylation of sphingosine.;

NCIt note : Sphingosine kinase 1 catalyzes the conversion of sphingosine to sphingosine-1-phosphate, which, in turn, mediates signal transduction pathways that regulate cell proliferation, cell migration, apoptosis and angiogenesis.;

Details

Origin ID

C92513;

UMLS CUI

C4282039;

OMIM relation
- Sphingosine kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- SPHK1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Metabolic Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Sphingolipid Metabolism Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 1 Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Calcium Signaling [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Phospholipid Metabolism [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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