" /> HCK wt Allele - CISMeF





Preferred Label : HCK wt Allele;

NCIt synonyms : Hemopoietic Cell Kinase wt Allele; JTK9;

NCIt definition : Human HCK wild-type allele is located within 20q11-q12 and is approximately 50 kb in length. This allele, which encodes tyrosine-protein kinase HCK protein, is involved in signal transduction.;

NCIt note : The HCK gene is expressed primarily in hematopoietic cell types, especially those of myeloid lineage and particularly in mature granulocytes and monocytes. Tyrosine-protein kinase HCK protein may play a role in activation of the respiratory burst, neutrophil migration and degranulation of neutrophils. Two isoforms of this protein, which differ in subcellular localization, are produced by alternate translation initiation. Activation of HCK protein facilitates the replication of human immunodeficiency virus type 1.;

GenBank Accession Number : NM_002110;

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30/04/2024


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