CFL1 wt Allele

Preferred Label : CFL1 wt Allele;

NCIt synonyms : Cofilin 1 (Non-Muscle) wt Allele; CFL;

NCIt definition : Human CFL1 wild-type allele is located in the vicinity of 11q13 and is approximately 4 kb in length. This allele, which encodes cofilin-1 protein, is involved in the regulation of actin polymerization.;

NCIt note : Increased expression of the CFL1 gene may be both a prognostic indicator for nonsmall cell lung cancer and a biomarker for drug resistant nonsmall cell lung cancer. (Cancer, 2010; 116: 3645-3655.);

GenBank Accession Number : X95404;

Details

Origin ID

C97285;

UMLS CUI

C3273327;

OMIM relation
- Cofilin 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 11q13 [NCIt concept]
gene_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- CCR3 Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Rac1 Cell Motility Signaling Pathway [NCIt concept]
- Rho Cell Motility Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cytoskeletal Modeling [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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