Rac1 Cell Motility Signaling Pathway

Preferred Label : Rac1 Cell Motility Signaling Pathway;

NCIt related terms : Rac 1 cell motility signaling pathway;

Alternative definition : BIOCARTA: Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular signals. Several changes in cytoskeletal structure and other aspects of cell structure are involved in cell motility. Rac-1 is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors, including Trio and Vav. Sos-1 is involved in Ras signaling and also acts as a GEF for Rac to transduce signals between Ras and Rac. SWAP-70 is a Rac GEF that binds IP3 and transduces signals from tyrosine kinases to Rac to modulate the cytoskeleton and cause membrane ruffling. GAPs are GTPase- activating proteins. Rac stimulates the formation of actin-based structures such as filopodia and lamellipodia, while GAPs such as chimerin oppose the formation of these Rac dependent structures. Several different factors downstream of Rac act on cytoskeletal structure and other aspects of cell motility. Pak1 provides a direct link from Rac to cell motility through phosphorylation of the myosin light chain. Pak1 also phosphorylates and activates LIM kinase, which phosphorylates cofilin as one target. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kinase represses its activity. In neurons, Rac acts through the protein kinase cdk5 and p35 to phosphorylate and down regulate Pak1, increasing neuronal migration. Rac-1 also interacts with several other factors to regulate a variety of processes. Interaction of Por1 with Rac-1 is involved in membrane ruffling. WAVE is a member of the WASP family of proteins that regulate actin organization and that is involved in Rac signaling to cause membrane ruffling. Interaction of Rac-1 with MEKK1 integrates Rac signaling with pathways signaling through map kinases. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_rac1Pathway;

Details

Origin ID

C39208;

UMLS CUI

C1514677;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Cell Adhesion Molecule 1 [NCIt concept]
- Cofilin-1 [NCIt concept]
- Cyclin-Dependent Kinase 5 [NCIt concept]
- Cyclin-Dependent Kinase 5 Activator 1 [NCIt concept]
- LIM Domain Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Myosin Light Chain Kinase, Smooth Muscle [NCIt concept]
- N-Chimaerin [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Platelet-Derived Growth Factor Receptor Alpha [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RalA-Binding Protein 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Triple Functional Domain Protein [NCIt concept]
pathway_has_gene_element
- CADM1 wt Allele [NCIt concept]
- CDK5 wt Allele [NCIt concept]
- CDK5R1 wt Allele [NCIt concept]
- CFL1 wt Allele [NCIt concept]
- CHN1 wt Allele [NCIt concept]
- LIMK1 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MYLK wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PDGFRA wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RALBP1 wt Allele [NCIt concept]
- TRIO wt Allele [NCIt concept]
- VAV1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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