Platelet-Derived Growth Factor Receptor Alpha

Preferred Label : Platelet-Derived Growth Factor Receptor Alpha;

NCIt synonyms : CD140a Antigen; EC 2.7.1.112; Alpha Platelet-Derived Growth Factor Receptor; PDGFRA; PDGF-R-Alpha; CD140 Antigen-Like Family Member A; Platelet-Derived Growth Factor Alpha Receptor; CD140a; Platelet-Derived Growth Factor Receptor 2; Alpha-Type Platelet-Derived Growth Factor Receptor; PDGFR-Alpha; PDGFR-2; EC 2.7.10.1; Platelet-Derived Growth Factor Receptor Alpha Polypeptide;

NCIt definition : Platelet-derived growth factor receptor alpha (1089 aa, 123 kDa) is encoded by the human PDGFRA gene. This protein is involved in ligand binding, tyrosine phosphorylation and receptor signaling.;

NCIt note : The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink);

Details

Origin ID

C30163;

UMLS CUI

C3853694;

Currated CISMeF NLP mapping
- receptor, Platelet-Derived growth factor alpha [MeSH concept]
- receptor, platelet-derived growth factor alpha [MeSH Descriptor]
OMIM relation
- Platelet-derived growth factor receptor, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- PDGFRA Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- PDGFRA NP_006197.1:p.D842V [NCIt concept]
- PDGFRA NP_006197.1:p.K385I [NCIt concept]
- PDGFRA NP_006197.1:p.K385L [NCIt concept]
- PDGFRA NP_006197.1:p.K385X [NCIt concept]
- PDGFRA Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Migration Pathway [NCIt concept]
- EGF Receptor Downregulation by CBL Pathway [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Rac1 Cell Motility Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Avapritinib [NCIt concept]
- Olaratumab [NCIt concept]
- PDGFR alpha/KIT Mutant-specific Inhibitor NB003 [NCIt concept]
- Ripretinib [NCIt concept]
- Tovetumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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