Erk1/Erk2 MAPK Signaling Pathway

Preferred Label : Erk1/Erk2 MAPK Signaling Pathway;

NCIt synonyms : Erk1 Erk2 MAPK Signaling Pathway;

Alternative definition : BIOCARTA: The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, and MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_erkPathway;

Details

Origin ID

C39072;

UMLS CUI

C1516956;

Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Beta-Nerve Growth Factor [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short [NCIt concept]
- Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms XLas [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Platelet-Derived Growth Factor Receptor Alpha [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase R [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-5 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 16 [NCIt concept]
pathway_has_gene_element
- EGFR wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- GNAS wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MKNK1 wt Allele [NCIt concept]
- MKNK2 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NGF wt Allele [NCIt concept]
- NGFR wt Allele [NCIt concept]
- PDGFRA wt Allele [NCIt concept]
- PPP2R3B wt Allele [NCIt concept]
- PTPRR wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RPS6KA5 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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