NCIt related terms : Anti-PDGFR Alpha Monoclonal Antibody MEDI-575;
NCIt definition : A humanized monoclonal antibody directed against the platelet-derived growth factor
receptor (PDGFR) alpha with potential antineoplastic activity. Tovetumab inhibits
activation of the cell-surface tyrosine kinase PDGFR alpha subunit and subsequent
triggering of mitogenic signaling pathways, including the JAK/STAT, PI3K/Akt, and
MAP kinase pathways. PDGFR alpha acts as a mitogenic signaling receptor for cells
of mesenchymal origin and inhibition of receptor activity may inhibit tumor cell proliferation.;
UNII : 2XY62K75UV;
CAS number : 1243266-04-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1243266-04-7
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