" /> Tovetumab - CISMeF





Preferred Label : Tovetumab;

NCIt synonyms : Anti-Platelet-Derived Growth Factor Receptor Alpha Monoclonal Antibody MEDI-575;

NCIt related terms : Anti-PDGFR Alpha Monoclonal Antibody MEDI-575;

NCIt definition : A humanized monoclonal antibody directed against the platelet-derived growth factor receptor (PDGFR) alpha with potential antineoplastic activity. Tovetumab inhibits activation of the cell-surface tyrosine kinase PDGFR alpha subunit and subsequent triggering of mitogenic signaling pathways, including the JAK/STAT, PI3K/Akt, and MAP kinase pathways. PDGFR alpha acts as a mitogenic signaling receptor for cells of mesenchymal origin and inhibition of receptor activity may inhibit tumor cell proliferation.;

UNII : 2XY62K75UV;

CAS number : 1243266-04-7;

Molecule name : MEDI-575;

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28/07/2025


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