" /> Avapritinib - CISMeF





Preferred Label : Avapritinib;

NCIt synonyms : PDGFR alpha/KIT Mutant-specific Inhibitor BLU-285; (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1Hpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-yl)pyrimidin-5-yl)ethan-1-amine;

NCIt definition : An orally bioavailable inhibitor of specific mutated forms of platelet-derived growth factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit (SCFR), with potential antineoplastic activity. Upon oral administration, avapritinib specifically binds to and inhibits specific mutant forms of PDGFRa and c-Kit, including the PDGFRa D842V mutant and various KIT exon 17 mutants. This results in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways and the inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit mutants. PDGFRa and c-Kit, protein tyrosine kinases and tumor-associated antigens (TAAs), are mutated in various tumor cell types; they play key roles in the regulation of cellular proliferation.;

UNII : 513P80B4YJ;

InChIKey : DWYRIWUZIJHQKQ-SANMLTNESA-N;

CAS number : 1703793-34-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1703793-34-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : AYVAKIT; Ayvakyt;

Molecule name : BLU-285; CS3007;

NCI Metathesaurus CUI : CL498221;

Codes from synonyms : 25334;

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14/05/2024


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