Preferred Label : PDGFR alpha/KIT Mutant-specific Inhibitor NB003;
NCIt definition : An orally bioavailable inhibitor of specific mutated forms of platelet-derived growth
factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit
(SCFR; CD117), with potential antineoplastic activity. Upon oral administration, PDGFR
alpha/KIT mutant-specific inhibitor NB003 specifically targets, binds to and inhibits
specific mutant forms of PDGFRa and c-Kit. This results in the inhibition of PDGFRa-
and c-Kit-mediated signal transduction pathways and the inhibition of proliferation
in tumor cells that express these PDGFRa and c-Kit mutants. PDGFRa and c-Kit, protein
tyrosine kinases, are upregulated or mutated in various tumor cell types; they play
key roles in the regulation of cellular proliferation and resistance to chemotherapy.;
Molecule name : NB 003; NB-003;
NCI Metathesaurus CUI : CL1663704;
Origin ID : C181080;
UMLS CUI : C5556836;
Semantic type(s)
- concept_is_in_subset
- has_target
