Preferred Label : PDGFR alpha/KIT Mutant-specific Inhibitor NB003;
NCIt synonyms : AZD 3229 Tosylate; N-(4-((5-Fluoro-7-(2-Methoxyethoxy)Quinazolin-4-Yl)Amino)Phenyl)-2-(4-(Propan-2-Yl)-1h-(1,2,3)Triazol-1-Yl)Acetamide
Tosylate; AZD3229 Tosylate; AZD-3229 Tosylate;
NCIt related terms : NB-003;
NCIt definition : The tosylate salt form of NB003, an orally bioavailable inhibitor of specific mutated
forms of platelet-derived growth factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem
cell factor receptor c-Kit (SCFR; CD117), with potential antineoplastic activity.
Upon oral administration, PDGFR alpha/KIT mutant-specific inhibitor NB003 specifically
targets, binds to and inhibits specific mutant forms of PDGFRa and c-Kit. This results
in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways and the
inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit mutants.
PDGFRa and c-Kit, protein tyrosine kinases, are upregulated or mutated in various
tumor cell types; they play key roles in the regulation of cellular proliferation
and resistance to chemotherapy.;
UNII : R3X99P2H4L;
CAS number : 2248003-71-4;
Molecule name : NB 003; NB-003;
NCI Metathesaurus CUI : CL1663704;
Origin ID : C181080;
UMLS CUI : C5556836;
Semantic type(s)
- concept_is_in_subset
- has_target
