" /> Ubavitinib Tosylate - CISMeF





Preferred Label : Ubavitinib Tosylate;

NCIt synonyms : AZD 3229 Tosylate; N-(4-((5-Fluoro-7-(2-Methoxyethoxy)Quinazolin-4-Yl)Amino)Phenyl)-2-(4-(Propan-2-Yl)-1h-(1,2,3)Triazol-1-Yl)Acetamide Tosylate; AZD3229 Tosylate; AZD-3229 Tosylate; PDGFR alpha/KIT Mutant-specific Inhibitor NB003;

NCIt related terms : NB-003;

NCIt definition : The tosylate salt form of NB003, an orally bioavailable inhibitor of specific mutated forms of platelet-derived growth factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit (SCFR; CD117), with potential antineoplastic activity. Upon oral administration, ubavitinib specifically targets, binds to and inhibits specific mutant forms of PDGFRa and c-Kit. This results in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways and the inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit mutants. PDGFRa and c-Kit, protein tyrosine kinases, are upregulated or mutated in various tumor cell types; they play key roles in the regulation of cellular proliferation and resistance to chemotherapy.;

UNII : R3X99P2H4L;

CAS number : 2248003-71-4;

Molecule name : NB 003; NB-003;

NCI Metathesaurus CUI : CL1663704;

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01/08/2025


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