" /> Ubavitinib - CISMeF





Preferred Label : Ubavitinib;

NCIt synonyms : NB 003 Free Base; N-(4-((5-Fluoro-7-(2-Methoxyethoxy)Quinazolin-4-Yl)Amino)Phenyl)-2-(4-(Propan-2-Yl)-1h-(1,2,3)Triazol-1-Yl)Acetamide; NB-003 Free Base; NB003 Free Base;

NCIt definition : An orally bioavailable inhibitor of specific mutated forms of platelet-derived growth factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit (SCFR; CD117), with potential antineoplastic activity. Upon oral administration, ubavitinib specifically targets, binds to and inhibits specific mutant forms of PDGFRa and c-Kit. This results in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways and the inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit mutants. PDGFRa and c-Kit, protein tyrosine kinases, are upregulated or mutated in various tumor cell types; they play key roles in the regulation of cellular proliferation and resistance to chemotherapy.;

UNII : 9ZGC48P3RV;

CAS number : 2248003-60-1;

Molecule name : AZD 3229; AZD-3229;

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21/08/2025


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