NCIt definition : An orally bioavailable inhibitor of specific mutated forms of platelet-derived growth
factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit
(SCFR; CD117), with potential antineoplastic activity. Upon oral administration, ubavitinib
specifically targets, binds to and inhibits specific mutant forms of PDGFRa and c-Kit.
This results in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways
and the inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit
mutants. PDGFRa and c-Kit, protein tyrosine kinases, are upregulated or mutated in
various tumor cell types; they play key roles in the regulation of cellular proliferation
and resistance to chemotherapy.;