Cell Migration Pathway

Preferred Label : Cell Migration Pathway;

NCIt related terms : Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration;

Alternative definition : BIOCARTA: Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals, and fibroblast response to injury. Cells can migrate in a specific direction in response to extracellular signals through pathways that trigger changes in the cytoskeleton, particularly actin filaments, increasing lamellipodia and filopodia formation and decreasing focal adhesions. Factors like PDGF activate PI3 kinase and multiple pathways downstream to stimulate cell migration. One pathway regulating migration through the p85 regulatory subunit of PI3 kinase does not require PI3-kinase activity. In this pathway, p85 of PI3-kinase activates cdc42, which activates N-Wasp (Wiskott-Aldrich Syndrome Protein) to regulate ARP-2/3. ARP-2/3 is a complex of proteins localized at the leading edge of moving cells that nucleates the formation of new actin fibers and interacts with Wasp to stimulate migration. The cdc42 pathway also regulates p21-activate kinase 1 (PAK1). Another pathway by which PI3 kinase regulates migration is through the small GTPase Rac. PAK1 is a downstream target of Rac as well as cdc42. Downstream of Rac and PAK1, Myosin light chain kinase (MLCK) phosphorylates myosin light chain to increase cell migration. The regulation of the localization and activity of signaling factors creates coordinated pathways linking extracellular signals and cellular migration. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_cdc42racPathway;

Details

Origin ID

C39021;

UMLS CUI

C1516352;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Actin-Related Protein 2/3 Complex Subunit 1B [NCIt concept]
- Cell Division Control Protein 42 Homolog [NCIt concept]
- Neural Wiskott-Aldrich Syndrome Protein [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Platelet-Derived Growth Factor Receptor Alpha [NCIt concept]
- Platelet-Derived Growth Factor Subunit A [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
pathway_has_gene_element
- ARPC1B wt Allele [NCIt concept]
- CDC42 wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PDGFA wt Allele [NCIt concept]
- PDGFRA wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- WASL wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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