Phospholipid Signaling Pathway

Preferred Label : Phospholipid Signaling Pathway;

NCIt related terms : Phospholipids as signaling intermediaries;

Alternative definition : BIOCARTA: Sphingosine-1-phosphate (S1P) is an example of a lipid messenger with both intracellular and extracellular functions. Intracellularly S1P regulates proliferation and survival; extracellularly S1P is a ligand for EDG1 (also known as S1P1). Activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine, increases cellular levels of S1P. Inhibitors of SPHK block formation of S1P and inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (PDGF) and PMA. In a study using endothelial cells it was demonstrated that S1P induces activation of alpha-v and B3 integrins via RhoA. S1P also activates Akt via Gi and PI3K. The activated Akt phosphorylates the Edg1 receptor on threonine 236 leading to the activation of Rac1 and subsequent signals leading to actin assembly, chemotaxis and lamellipodia formation. Edg1 stimulation also leads to the activation of the ERK signaling cascade resulting in anti-apoptotic reversal, proliferation and cell survival. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_edg1Pathway;

Details

Origin ID

C39055;

UMLS CUI

C1519058;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- A-Kinase Anchor Protein SPHKAP [NCIt concept]
- Acid Ceramidase [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Integrin Alpha-V [NCIt concept]
- Integrin Beta-3 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Platelet-Derived Growth Factor Receptor Alpha [NCIt concept]
- Platelet-Derived Growth Factor Subunit A [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Sphingosine 1-Phosphate Receptor 1 [NCIt concept]
- Sphingosine 1-Phosphate Receptor 2 [NCIt concept]
- Sphingosine Kinase 1 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- ASAH1 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- ITGAV wt Allele [NCIt concept]
- ITGB3 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- PDGFA wt Allele [NCIt concept]
- PDGFRA wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- S1PR1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SPHK1 wt Allele [NCIt concept]
- SPHKAP wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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