Cyclin-Dependent Kinase 5

Preferred Label : Cyclin-Dependent Kinase 5;

NCIt synonyms : Tau Protein Kinase II Catalytic Subunit; Cell Division Kinase 5; Serine/Threonine-Protein Kinase PSSALRE; Cyclin-Dependent Kinase-5; TPKII Catalytic Subunit; CDK5; EC 2.7.11.22; Cell Division Protein Kinase 5;

NCIt definition : Cyclin-dependent kinase 5 (292 aa, 33 kDa) is encoded by the human CDK5 gene. This protein plays a role in protein phosphorylation and may be involved in cell cycle regulation.;

NCIt note : A hetero-dimeric (catalytic/regulatory subunits) serine/threonine protein kinase involved in cell cycle control. Predominantly neuronal, Cdk5 belongs to the CDC2/CDKX subfamily, interacts with D1- and D3-type G1 Cyclins, and phosphorylates histone H1, Tau, Map2, NF-H, and NF-M. (from SWISS-PROT, OMIM);

Details

Origin ID

C17785;

UMLS CUI

C1565306;

Currated CISMeF NLP mapping
- Cyclin-Dependent kinase 5 [MeSH Descriptor]
- Cyclin-Dependent kinase 5 [MeSH concept]
OMIM relation
- Cyclin-dependent kinase 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CDK5 protein, human [MeSH concept]
- CDK5 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CDK5 Gene [NCIt concept]
- Cell Cycle Gene [NCIt concept]
- Cyclin-Dependent Kinase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Neuron [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway BioCarta [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- CK1/CDK5 Regulation Pathway [NCIt concept]
- FosB Drug-induction Pathway [NCIt concept]
- LIS1 Pathway [NCIt concept]
- MAP Kinase Downregulation Pathway [NCIt concept]
- Rac1 Cell Motility Signaling Pathway [NCIt concept]
- Reelin Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cytokinesis [NCIt concept]
- Neural Development [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Dinaciclib [NCIt concept]

Keyword's position in hierarchy(ies) :

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