Mitogen-Activated Protein Kinase Kinase Kinase 1

Preferred Label : Mitogen-Activated Protein Kinase Kinase Kinase 1;

NCIt synonyms : MEK Kinase; Mitogen-Activated Kinase Kinase Kinase 1; MEK Kinase 1; MAPK/ERK Kinase Kinase 1; MAP3K1; MEKK 1; MEKK1 Protein; EC 2.7.11.25; MEKK-1;

NCIt definition : Mitogen-activated protein kinase kinase kinase 1 (1512 aa, 164 kDa) is encoded by the human MAP3K1 gene. This protein plays a role in signal transduction.;

Details

Origin ID

C26486;

UMLS CUI

C1367798;

OMIM relation
- Mitogen-activated protein kinase kinase kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP3K1 protein, human [MeSH concept]
- MAP3K1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP3K1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Selumetinib [NCIt concept]
- Selumetinib Sulfate [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- 4-1BB-Dependent Immune Response Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- CD40L Signaling Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Formyl Peptide Receptor 1 Signaling Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Rac1 Cell Motility Signaling Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T-Cell Antiapoptosis Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- TNFR2 Signaling Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- MEK-1/MEKK-1 Inhibitor E6201 [NCIt concept]

Keyword's position in hierarchy(ies) :

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