Myosin Light Chain Kinase, Smooth Muscle

Preferred Label : Myosin Light Chain Kinase, Smooth Muscle;

NCIt synonyms : MYLK; Myosin, Light Polypeptide Kinase; MLCK; Myosin Light Chain Kinase, Smooth Muscle and Non-Muscle Isozymes; MLC Kinase; EC 2.7.1.117; Myosin Light Chain Kinase; smMLCK; Telokin; Kinase-Related Protein; EC 2.7.11.18; KRP; Myosin Light Polypeptide Kinase;

NCIt definition : Myosin light chain kinase, smooth muscle (1914 aa, 211 kDa) is encoded by the human MYLK gene. This protein plays a role in both myosin phosphorylation and smooth muscle cell contraction.;

NCIt note : Telokin, a small protein identical in sequence to the C terminus of myosin light chain kinase, is expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments is transcribed from the MYLK gene using a separate promoter in an intron in the 3' region.;

Details

Origin ID

C30086;

UMLS CUI

C1567740;

Automatic exact mappings (from CISMeF team)
- MLCK (480-501) [MeSH concept]
- Myosin light chain kinase [OMIM gene]
- Myosin light chain kinase 2, skeletal muscle [ORDO Gene]
- Strn-Mlck protein, drosophila [MeSH Supplementary Concept]
- cardiac myosin light chain kinase, human [MeSH Supplementary Concept]
- mylk3 protein, zebrafish [MeSH Supplementary Concept]
- myosin light chain kinase [HGNC gene]
- myosin light chain kinase [ORDO Gene]
- myosin light chain kinase 3 [HGNC gene]
- myosin light chain kinase activity [GO term]
- non-muscle myosin light chain kinase, rabbit [MeSH Supplementary Concept]
- non-muscle myosin light-chain kinase, mouse [MeSH Supplementary Concept]
- obscurin-MLCK [MeSH Supplementary Concept]
- speg protein, mouse [MeSH Supplementary Concept]
- telokin [MeSH concept]
- telokin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Myosin-Light-Chain kinase [MeSH Descriptor]
- Myosin-Light-Chain kinase [MeSH concept]
False automatic mappings
- Myosin light-chain kinase (substance) [SNOMED CT concept]
OMIM relation
- Myosin light chain kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MYLK protein, human [MeSH Supplementary Concept]
- MYLK protein, human [MeSH concept]
- Myosin light-chain kinase (substance) [SNOMED CT concept]
- Myosin-Light-Chain kinase [MeSH Descriptor]
- Myosin-Light-Chain kinase [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MYLK Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gastric Acid Secretion Pathway [NCIt concept]
- Myosin Phosphatase Pathway [NCIt concept]
- Rac1 Cell Motility Signaling Pathway [NCIt concept]
- Rho Cell Motility Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Muscle Contraction [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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