MYLK wt Allele

Preferred Label : MYLK wt Allele;

NCIt synonyms : Myosin, Light Polypeptide Kinase wt Allele; MLCK210; MLCK108; KRP; FLJ12216; MLCK;

NCIt definition : Human MYLK wild-type allele is located within 3q21 and is approximately 272 kb in length. This allele, which encodes myosin light chain kinase, smooth muscle and non-muscle isozymes protein, is involved in myosin light chain activation, vascular permeability and the formation of edema in tissues.;

NCIt note : The MYLK gene produces seven RNA transcript variants via alternative splicing. Alternative initiation results in the formation of six isoforms of myosin light chain kinase, smooth muscle and non-muscle isozymes protein and two isoforms of telokin.;

GenBank Accession Number : NM_053025;

Details

Origin ID

C51249;

UMLS CUI

C1706585;

Currated CISMeF NLP mapping
- MLCK (480-501) [MeSH concept]
OMIM relation
- Myosin light chain kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 3q21 [NCIt concept]
gene_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gastric Acid Secretion Pathway [NCIt concept]
- Myosin Phosphatase Pathway [NCIt concept]
- Rac1 Cell Motility Signaling Pathway [NCIt concept]
- Rho Cell Motility Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_plays_role_in_process
- Muscle Contraction [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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