Protein Kinase C Delta Type

Preferred Label : Protein Kinase C Delta Type;

NCIt synonyms : EC 2.7.10.2; EC 2.7.11.13; nPKC-Delta; Tyrosine-Protein Kinase PRKCD; PRKCD;

NCIt definition : Protein kinase C delta type (676 aa, 78 kDa) is encoded by the human PRKCD gene. This protein plays a role in the regulation of apoptosis.;

NCIt note : Protein kinase C delta type is cleaved by caspase-3 to yield a regulatory subunit and a catalytic subunit and results in activation of kinase activity. The catalytic subunit is also known as sphingosine-dependent protein kinase-1 (SDK1). (UniProt); Protein kinase C delta type may possess tyrosine-protein kinase activity. (UniProt);

Details

Origin ID

C150120;

UMLS CUI

C1566443;

Automatic exact mappings (from CISMeF team)
- Protein kinase C, delta [OMIM gene]
- calcium-independent protein kinase C [MeSH Supplementary Concept]
- nPKC-delta [MeSH concept]
- protein kinase C activity [GO term]
- protein kinase C delta [ORDO Gene]
OMIM relation
- Protein kinase C, delta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PRKCD protein, human [MeSH Supplementary Concept]
- PRKCD protein, human [MeSH concept]
- nPKC-delta [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PRKCD Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alpha-Synuclein Signaling Pathway [NCIt concept]
- Autophagy Regulation Pathway [NCIt concept]
- Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Hedgehog Signaling Events Mediated by Gli Family Proteins [NCIt concept]
- IGF1 Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Interferon-Gamma Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- NTRK1/MAPK Signaling Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
- Thromboxane A2 Receptor Family Signaling Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
- VEGFR1 and VEGFR2 Signaling [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
- p53 Pathway for Transcriptional Regulation [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Regulation of Cell Death Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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