C2 Domain - CISMeF

Preferred Label : C2 Domain;

NCIt definition : Some isozymes of protein kinase C (PKC) contain a domain, known as C2, of about 116 amino-acid residues which is located between the two copies of the C1 domain (that bind phorbol esters and diacylglycerol) and the protein kinase catalytic domain. Regions with significant homology to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding. Since domains related to the C2 domain are also found in proteins that do not bind calcium, other putative functions for the C2 domain such as binding to inositol-1,3,4,5-tetraphosphate have been suggested. The 3D structure of the C2 domain of synaptotagmin has been reported, the domain forms an eight-stranded sandwich constructed around a conserved 4-stranded motif, designated a C2 key. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. (From Pfam 00168);

Details

Origin ID

C26042;

UMLS CUI

C1511359;

Automatic exact mappings (from CISMeF team)
- C2 Domains [MeSH Descriptor]
- C2 Domains [MeSH concept]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- C2 Domains [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Epsilon-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Calcium-Dependent Secretion Activator 2 [NCIt concept]
- Coiled-Coil and C2 Domain-Containing Protein 2A [NCIt concept]
- Copine-1 [NCIt concept]
- Copine-7 [NCIt concept]
- Cytosolic Phospholipase A2 [NCIt concept]
- Cytosolic Phospholipase A2 Beta [NCIt concept]
- Cytosolic Phospholipase A2 Delta [NCIt concept]
- Cytosolic Phospholipase A2 Gamma [NCIt concept]
- Cytosolic Phospholipase A2 Group IV [NCIt concept]
- E3 Ubiquitin-Protein Ligase Itchy Homolog [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- Inositol Polyphosphate 4-Phosphatase Type II [NCIt concept]
- Inositol Polyphosphate-4-Phosphatase Type I A [NCIt concept]
- Intersectin-1 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2 [NCIt concept]
- Perforin-1 [NCIt concept]
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta [NCIt concept]
- Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Gamma [NCIt concept]
- Protein KIBRA [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Kinase C Delta Type [NCIt concept]
- Protein Kinase C Epsilon Type [NCIt concept]
- Protein Piccolo [NCIt concept]
- Ras GTPase-Activating Protein 1 [NCIt concept]
- Ras GTPase-Activating Protein 2 [NCIt concept]
- Ras GTPase-Activating Protein nGAP [NCIt concept]
- Ras/Rap GTPase-Activating Protein SynGAP [NCIt concept]
- RasGAP-Activating-Like Protein 1 [NCIt concept]
- Serine/Threonine-Protein Kinase N1 [NCIt concept]
- Toll-Interacting Protein [NCIt concept]
- UV Radiation Resistance-Associated Gene Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients