NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2

Preferred Label : NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2;

NCIt synonyms : EC 6.3.2.-, Formerly; Atrophin-1 Interacting Protein 2; Atrophin-1-Interacting Protein 2; AIP2; WW Domain-Containing Protein 2; EC 2.3.2.26; WWP2;

NCIt definition : NEDD4-like E3 ubiquitin-protein ligase WWP2 (870 aa, 99 kDa) is encoded by the human WWP2 gene. This protein is involved in the mediation of protein ubiquitination.;

NCIt note : NEDD4-like E3 ubiquitin-protein ligase WWP2 may be involved in dedifferentiation or transformation of tumor cells and metastasis. (Oncogene, 2011; DOI: 10.1038/onc.2010.617.);

Details

Origin ID

C95564;

UMLS CUI

C1143404;

OMIM relation
- Ww domain-containing protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- WWP2 protein, human [MeSH concept]
- WWP2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
- WWP2 Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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