Ubiquitin Protein Ligase

Preferred Label : Ubiquitin Protein Ligase;

NCIt synonyms : Ubiquitin Protein Ligase Complex;

NCIt definition : Ubiquitin protein ligase enzymes catalyze the formation of a covalent peptide bond between the carboxy-terminal glycine of ubiquitin proteins and lysine alpha-amino group of other proteins. This typically marks proteins for either nonlysosomal proteasomal degradation or targeted transport. Ubiquitination requires sequential action of an activating enzyme, a conjugating enzyme, and a ligase.;

Details

Origin ID

C26065;

UMLS CUI

C1256818;

Automatic exact mappings (from CISMeF team)
- Ubiquitin--protein ligase (substance) [SNOMED CT concept]
- Ubiquitin-Protein ligases [MeSH concept]
- ubiquitin-protein ligases [MeSH Descriptor]
Biochemical function of gene products
- Ubiquitin-Conjugating Enzyme E2 C [NCIt concept]
Currated CISMeF NLP mapping
- Ubiquitin-Protein ligase complexes [MeSH concept]
- ubiquitin-protein ligase complexes [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Ubiquitin-Protein ligase complexes [MeSH concept]
- ubiquitin-protein ligase complexes [MeSH Descriptor]
gene_encodes_gene_product
- Ubiquitin-Activating Enzyme Gene [NCIt concept]
gene_product_has_biochemical_function
- Ligase [NCIt concept]
gene_product_has_chemical_classification
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitination [NCIt concept]
has_gene_product_element
- Ankyrin Repeat and SOCS Box Protein 2 [NCIt concept]
- BRCA1-Associated RING Domain Protein 1 [NCIt concept]
- BTB/POZ Domain-Containing Adapter for CUL3-Mediated RhoA Degradation Protein 2 [NCIt concept]
- BTB/POZ Domain-Containing Protein 18 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 3 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 6 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 7 [NCIt concept]
- Breast Cancer Type 1 Susceptibility Protein [NCIt concept]
- Cullin-1 [NCIt concept]
- Cullin-3 [NCIt concept]
- Cullin-4A [NCIt concept]
- Cullin-4B [NCIt concept]
- Cyclin-Dependent Kinases Regulatory Subunit 2 [NCIt concept]
- DDB1- and CUL4-Associated Factor 1 [NCIt concept]
- DDB1- and CUL4-Associated Factor 5 [NCIt concept]
- Denticleless Protein Homolog [NCIt concept]
- E3 Ubiquitin Ligase TRAF3IP2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase AMFR [NCIt concept]
- E3 Ubiquitin-Protein Ligase ARIH1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Arkadia [NCIt concept]
- E3 Ubiquitin-Protein Ligase BRE1A [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- E3 Ubiquitin-Protein Ligase CCNB1IP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CHFR [NCIt concept]
- E3 Ubiquitin-Protein Ligase COP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase DTX1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase FANCL [NCIt concept]
- E3 Ubiquitin-Protein Ligase HACE1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase HERC2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase HUWE1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Itchy Homolog [NCIt concept]
- E3 Ubiquitin-Protein Ligase MARCH9 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MIB1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MYCBP2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Makorin-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Midline-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase NEDD4 [NCIt concept]
- E3 Ubiquitin-Protein Ligase NEURL1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Parkin [NCIt concept]
- E3 Ubiquitin-Protein Ligase Pellino Homolog 3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RAD18 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RBX1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RFWD3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RING2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF130 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF139 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF146 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF213 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF216 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF31 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF43 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF5 [NCIt concept]
- E3 Ubiquitin-Protein Ligase SIAH2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRAF7 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRAIP [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM13 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM21 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM23 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM33 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM36 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM37 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM38 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM56 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM63 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIP12 [NCIt concept]
- E3 Ubiquitin-Protein Ligase UBR5 [NCIt concept]
- E3 Ubiquitin-Protein Ligase UHRF1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase XIAP [NCIt concept]
- E3 Ubiquitin-Protein Ligase ZNRF3 [NCIt concept]
- E3 Ubiquitin-Protein Transferase [NCIt concept]
- E3 Ubiquitin/ISG15 Ligase TRIM25 [NCIt concept]
- F-Box Only Protein 11 [NCIt concept]
- F-Box Only Protein 3 [NCIt concept]
- F-Box Only Protein 31 [NCIt concept]
- F-Box/LRR-Repeat Protein 18 [NCIt concept]
- F-Box/LRR-Repeat Protein 19 [NCIt concept]
- F-Box/LRR-Repeat Protein 4 [NCIt concept]
- F-Box/WD Repeat-Containing Protein 1A [NCIt concept]
- F-Box/WD Repeat-Containing Protein 7 [NCIt concept]
- Helicase-Like Transcription Factor [NCIt concept]
- Kelch Repeat and BTB Domain-Containing Protein 4 [NCIt concept]
- Kelch-Like Protein 24 [NCIt concept]
- Kelch-Like Protein 40 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2 [NCIt concept]
- Probable E3 Ubiquitin-Protein Ligase DTX2 [NCIt concept]
- Protein Fem-1 Homolog C [NCIt concept]
- Protein Yippee-Like 5 [NCIt concept]
- RING Finger Protein 11 [NCIt concept]
- RanBP-Type and C3HC4-Type Zinc Finger-Containing Protein 1 [NCIt concept]
- S-Phase Kinase-Associated Protein 1 [NCIt concept]
- Short Transient Receptor Potential Channel 4-Associated Protein [NCIt concept]
- Speckle-Type POZ Protein [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 3 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Intermediary Factor 1-Alpha [NCIt concept]
- Tripartite Motif-Containing Protein 16 [NCIt concept]
- Tripartite Motif-Containing Protein 5 [NCIt concept]
- Ubiquitin Conjugation Factor E4 B [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 A [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 L3 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 R1 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 T [NCIt concept]
- Ubiquitin-Protein Ligase E3A [NCIt concept]
- V(D)J Recombination-Activating Protein 1 [NCIt concept]
- Zinc-Finger Protein RFP [NCIt concept]

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