E3 Ubiquitin-Protein Ligase HUWE1

Preferred Label : E3 Ubiquitin-Protein Ligase HUWE1;

NCIt synonyms : Mcl-1 Ubiquitin Ligase E3; HECT, UBA and WWE Domain Containing E3 Ubiquitin Protein Ligase 1; Homologous to E6AP Carboxyl Terminus Homologous Protein 9; HECT Domain Protein LASU1; URE-Binding Protein 1; HUWE1; LASU1; Large Structure of UREB1; Mule; HECT, UBA and WWE Domain Containing 1; BJ-HCC-24 Tumor Antigen; ARF-BP1; URE-B1; EC 2.3.2.26; HECT, UBA and WWE Domain-Containing Protein 1; ARF-Binding Protein 1; HECT-Type E3 Ubiquitin Transferase HUWE1; Upstream Regulatory Element-Binding Protein 1; HECT, UBA, and WWE Domains-Containing Protein 1;

NCIt definition : E3 ubiquitin-protein ligase HUWE1 (4374 aa, 482 kDa) is encoded by the human HUWE1 gene. This protein is involved in the modulation of ubiquitination of target proteins involved in DNA replication and repair, apoptosis, chromatin remodeling, circadian rhythms and tumor suppression.;

Details

Origin ID

C181821;

UMLS CUI

C1619903;

Automatic exact mappings (from CISMeF team)
- Equus asinus (male) X Equus caballus (female) intragenus hybrid (organism) [SNOMED CT concept]
- Golgi-associated, gamma-adaptin ear-containing, arf-binding protein 1 [OMIM gene]
- HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [HGNC gene]
- HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ORDO Gene]
- Hect, uba, and wwe domains-containing protein 1 [OMIM gene]
- Mules (physical object) [SNOMED CT concept]
- equidae [MeSH Descriptor]
- mule [SNOMED Notion]
- mules [MeSH concept]
OMIM relation
- Hect, uba, and wwe domains-containing protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HUWE1 protein, human [MeSH Supplementary Concept]
- HUWE1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HUWE1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- UBA Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
- p53 Pathway for Transcriptional Regulation [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- DNA Repair [NCIt concept]
- Protein Degradation Induction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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